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Literature summary extracted from

  • Chao, D.Y.; Chen, Y.; Chen, J.; Shi, S.; Chen, Z.; Wang, C.; Danku, J.M.; Zhao, F.J.; Salt, D.E.
    Genome-wide association mapping identifies a new arsenate reductase enzyme critical for limiting arsenic accumulation in plants (2014), PLoS Biol., 12, e1002009 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.20.99.1 expressed in Escherichia coli W3110 cells Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.20.99.1 arsenite + acceptor Arabidopsis thaliana
-
arsenate + reduced acceptor
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.20.99.1 Arabidopsis thaliana
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.20.99.1 root
-
Arabidopsis thaliana
-
1.20.99.1 shoot
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.20.99.1 arsenite + acceptor
-
Arabidopsis thaliana arsenate + reduced acceptor
-
?

Synonyms

EC Number Synonyms Comment Organism
1.20.99.1 HAC1
-
Arabidopsis thaliana

Expression

EC Number Organism Comment Expression
1.20.99.1 Arabidopsis thaliana enzyme expression is induced by arsenate up

General Information

EC Number General Information Comment Organism
1.20.99.1 malfunction plants lacking the enzyme lose their ability to efflux arsenite from roots, leading to both increased transport of arsenic into the central vascular tissue and on into the shoot. Loss of enzyme-encoded arsenic reduction leads to a significant increase in arsenic accumulation in shoots, causing an increased sensitivity to arsenate toxicity Arabidopsis thaliana
1.20.99.1 physiological function the enzyme functions to reduce arsenate to arsenite in the outer cell layer of the root, facilitating efflux of arsenic as arsenite back into the soil to limit both its accumulation in the root and transport to the shoot. Arsenate reduction by the enzyme in the pericycle may play a role in limiting arsenic loading into the xylem Arabidopsis thaliana