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Literature summary extracted from

  • Yang, K.; Monfared, S.R.; Monafared, R.S.; Wang, H.; Lundgren, A.; Brodelius, P.E.
    The activity of the artemisinic aldehyde ?11(13) reductase promoter is important for artemisinin yield in different chemotypes of Artemisia annua L. (2015), Plant Mol. Biol., 88, 325-340 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.92 gene DBR2, cloning, sequencing, and analysis of the promoter of the DBR2 gene, detailed overview. The activity of the artemisinic aldehyde DELTA11(13) reductase promoter is important for artemisinin yield in different chemotypes of Artemisia annua, quantitative real-time PCR expression analysis, overview Artemisia annua

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.92 artemisinic aldehyde + NADPH + H+ Artemisia annua
-
 (11R)-dihydroartemisinic aldehyde + NADP+
-
 ?
1.3.1.92 additional information Artemisia annua GC-MS analysis of dihydroartemisinic acid synthesized in different plant varieties, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.92 Artemisia annua C5H429 cvs. 2/39, Chongqing, and Anamed with high artemisin production, and cvs. Meise, Iran#8, Iran#14, Iran#24, and Iran#47 with low artemisin production
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.92 flower bud
-
 Artemisia annua
-
1.3.1.92 leaf
-
 Artemisia annua
-
1.3.1.92 additional information enzyme expression levels in different plant varieties, overview Artemisia annua
-
1.3.1.92 secretory trichome
-
 Artemisia annua
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.92 artemisinic aldehyde + NADPH + H+
-
 Artemisia annua (11R)-dihydroartemisinic aldehyde + NADP+
-
 ?
1.3.1.92 additional information GC-MS analysis of dihydroartemisinic acid synthesized in different plant varieties, overview Artemisia annua ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.92 Dbr2
-
 Artemisia annua
1.3.1.92 double bond reductase 2
-
 Artemisia annua

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.92 NADPH
-
 Artemisia annua

General Information

EC Number General Information Comment Organism
1.3.1.92 physiological function the enzyme plays an important role in the biosynthesis of the antimalarial artemisinin in Artemisia annua. The high artemisin producing plant varieties 2/39, Chongqing, and Anamed produce more artemisinin than arteannuin B, while the low artemisin producing plant varieties Meise, Iran#8, Iran#14, Iran#24, and Iran#47 produce more arteannuin B than artemisinin Artemisia annua