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Literature summary extracted from

  • Hammerbacher, A.; Raguschke, B.; Wright, L.; Gershenzon, J.
    Gallocatechin biosynthesis via a flavonoid 3',5'-hydroxylase is a defense response in Norway spruce against infection by the bark beetle-associated sap-staining fungus Endoconidiophora polonica (2018), Phytochemistry, 148, 78-86 .
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.81 2,3-(trans)-(+)-catechin + [reduced NADPH-hemoprotein reductase] + O2 Picea abies
-
 2,3-(trans)-(+)-gallocatechin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.81 dihydroquercetin + [reduced NADPH-hemoprotein reductase] + O2 Picea abies
-
 dihydromyricetin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.81 leucocyanidin + [reduced NADPH-hemoprotein reductase] + O2 Picea abies
-
 leucodelphinidin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.81 Picea abies
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.81 2,3-(trans)-(+)-catechin + [reduced NADPH-hemoprotein reductase] + O2
-
 Picea abies 2,3-(trans)-(+)-gallocatechin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.81 dihydroquercetin + [reduced NADPH-hemoprotein reductase] + O2
-
 Picea abies dihydromyricetin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.81 leucocyanidin + [reduced NADPH-hemoprotein reductase] + O2
-
 Picea abies leucodelphinidin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.81 CYP75A42
-
 Picea abies

Expression

EC Number Organism Comment Expression
1.14.14.81 Picea abies transcript abundance of the flavonoid 3',5'-hydroxylase gene increases significantly during infection with fungus Endoconidiophora polonica up

General Information

EC Number General Information Comment Organism
1.14.14.81 physiological function coexpression with Norway spruce and apple genes encoding the rest of the flavonoid pathway, PaCHS, PaF3H, PaF30H, MdDFR and PaLAR3, in Nicotiana benthamiana leaves. Catechin and 2,3-(trans)-(+)-gallocatechin accumulate in the leaves 7 days after Agrobacterium infiltration. There is a significant increase in the gallocatechin content of Norway spruce bark and wood after inoculation with the bark beetle-associated sap-staining fungus Endoconidiophora polonica. 2,3 (trans)-(+)-catechin is a stronger inhibitor of fungal growth, while 2,3 (trans)-(+)-gallocatechin is a stronger inhibitor of melanin biosynthesis Picea abies