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Literature summary extracted from

  • Takahashi, H.; Kutasy, B.; Pes, L.; Paradisi, F.; Puri, P.
    Decidual beta-carotene-15,15'-oxygenase-1 and 2 (BCMO1,2) expression is increased in nitrofen model of congenital diaphragmatic hernia (2015), Pediatr. Surg. Int., 31, 37-43 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.63 isozyme Bcmo1, quantitative real-time PCR expression analysis Rattus norvegicus
1.13.11.63 isozyme Bcmo2, quantitative real-time PCR expression analysis Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.63 cytosol
-
 Rattus norvegicus 5829
-
1.13.11.63 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.63 beta-carotene + O2 Rattus norvegicus
-
 2 all-trans-retinal
-
 ?
1.13.11.63 beta-carotene + O2 Rattus norvegicus Sprague–Dawley
-
 2 all-trans-retinal
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.63 Rattus norvegicus A3KN98
-
-
1.13.11.63 Rattus norvegicus Q91XT5
-
-
1.13.11.63 Rattus norvegicus Sprague–Dawley A3KN98
-
-
1.13.11.63 Rattus norvegicus Sprague–Dawley Q91XT5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.63 liver fetal Rattus norvegicus
-
1.13.11.63 lung left, fetal Rattus norvegicus
-
1.13.11.63 additional information quantitative real-time PCR expression analysis, no difference in the trophoblastic BCMO1 and 2 immunoreactivity in congenital diaphragmatic hernia, CDH, placenta compared to controls Rattus norvegicus
-
1.13.11.63 placenta maternal Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.63 beta-carotene + O2
-
 Rattus norvegicus 2 all-trans-retinal
-
 ?
1.13.11.63 beta-carotene + O2
-
 Rattus norvegicus Sprague–Dawley 2 all-trans-retinal
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.63 Bcmo1
-
 Rattus norvegicus
1.13.11.63 Bcmo2
-
 Rattus norvegicus
1.13.11.63 beta-carotene-15,15'-oxygenase-1
-
 Rattus norvegicus
1.13.11.63 beta-carotene-15,15'-oxygenase-2
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.13.11.63 Rattus norvegicus nitrofen increases maternal but not fetal Bcmo1,2 expression in the placenta in nitrofen-induced congenital diaphragmatic hernia, CDH, group. The markedly increased decidual Bcmo1,2 expression suggests that nitrofen may trigger local, decidual retinol synthesis in the nitrofen model of CDH up

General Information

EC Number General Information Comment Organism
1.13.11.63 malfunction placental expression of BCMO1 and BCMO2 is altered in nitrofen-exposed rat fetuses with congenital diaphragmatic hernia, CDH. Pulmonary hypoplasia and congenital diaphragmatic hernia pathogenesis involve low pulmonary retinol levels and disrupted retinoid signaling pathway. Markedly increased decidual Bcmo1,2 immunoreactivity is observed in placental CDH group compared to controls, although not in pulmonary and liver immunoreactivity Rattus norvegicus
1.13.11.63 physiological function retinoids are essential for fetal and lung development. Beta-carotene (BC) is the main dietary retinoid source and beta-carotene-15,15'-oxygenase-1 and 2 (Bcmo1,2) is the primary enzyme generating retinoid from BC in adult mammalian tissues. Placenta has a major role in the retinol homeostasis in fetal life: Since there is no fetal retinol synthesis, maternal retinol has to cross the placenta. The placental BCMO1 and 2 expression is tightly controlled by placental retinol level and the maternal ROH status controls fetal uptake of intact beta-carotene Rattus norvegicus