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Literature summary extracted from

  • Xia, M.; Yao, L.; Zhang, Q.; Wang, F.; Mei, H.; Guo, X.; Huang, W.
    Long noncoding RNA HOTAIR promotes metastasis of renal cell carcinoma by up-regulating histone H3K27 demethylase JMJD3 (2017), Oncotarget, 8, 19795-19802 .
No PubMed abstract available

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.B1 histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2 Homo sapiens
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 histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.B1 Homo sapiens O15054
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.B1 kidney
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 Homo sapiens
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1.14.18.B1 renal cell carcinoma cell
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 Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.B1 histone H3 N6,N6,N6-trimethyl-L-lysine27 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3 N6,N6-dimethyl-L-lysine27 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.B1 histone H3K27 demethylase
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 Homo sapiens
1.14.18.B1 JMJD3
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 Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.18.B1 Homo sapiens upregulation of histone H3K27 demethylase JMJD3 by long noncoding RNA HOTAIR, i.e. homeobox transcript antisense intergenic RNA, a kind of non-protein coding transcripts longer than 200 nucleotides. HOTAIR is an important promoter in metastasis of renal cell carcinoma and also plays a dual regulatory role in chromatin state by effecting both histone metylation and demethylation at different gene loci. HOTAIR can affect histone H3K27 methylation and its target genes' expression up

General Information

EC Number General Information Comment Organism
1.14.18.B1 malfunction histone demethylase JMJD3 is reduced and its target gene Snai1 expression is downregulated after HOTAIR suppression. The cell migration is inhibited in scratch test and transwell assay after HOTAIR knockdown Homo sapiens
1.14.18.B1 physiological function long noncoding RNA HOTAIR, i.e. homeobox transcript antisense intergenic RNA, kind of non-protein coding transcripts longer than 200 nucleotides, promotes metastasis of renal cell carcinoma by upregulating histone H3K27 demethylase JMJD3. RNA HOTAIR expression is elevated in tissues of renal cell carcinoma compared to adjacent normal tissues, and positively correlates with metastasis. HOTAIR is an important promoter in metastasis of renal cell carcinoma and also plays a dual regulatory role in chromatin state by effecting both histone metylation and demethylation at different gene loci Homo sapiens