EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.18.1 | 2-ethyl-3-hydroxy-4H-pyran-4-one | - |
Agaricus bisporus | |
1.14.18.1 | 3-hydroxy-1,2-dimethyl-4(1H)-pyridone | - |
Agaricus bisporus | |
1.14.18.1 | 5-hydroxy-4-oxo-4H-pyran-2-carboxylic acid | - |
Agaricus bisporus | |
1.14.18.1 | kojic acid | - |
Agaricus bisporus | |
1.14.18.1 | additional information | the inhibition of tyrosinase by analogues of kojic acid, main interactions occurring between inhibitors-tyrosinase complexes and influence of divalent cation (Cu2+) in enzymatic inhibition are analysed using molecular docking, molecular dynamic simulations and linear interaction energy (LIE) method, using the three-dimensional structure of enzyme AbTYR in complex with inhibitor tropolone, PDB 2Y9X, overview. No inhibition by 3-hydroxy-2-methyl-4-pyrone. Tyrosinase displays various inhibition patterns | Agaricus bisporus | |
1.14.18.1 | tropolone | - |
Agaricus bisporus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.14.18.1 | Cu2+ | the enzyme's catalytic site contains two divalent copper cations chelated by His61, His85, His94, His259, His263 and His294 catalytic amino acid residue | Agaricus bisporus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.1 | 2 L-dopa + O2 | Agaricus bisporus | - |
2 dopaquinone + 2 H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.18.1 | Agaricus bisporus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.18.1 | 2 L-dopa + O2 | - |
Agaricus bisporus | 2 dopaquinone + 2 H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.18.1 | AbTYR | - |
Agaricus bisporus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.14.18.1 | 7.2 | - |
assay at | Agaricus bisporus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.14.18.1 | additional information | - |
additional information | inhibition kinetic analysis | Agaricus bisporus | |
1.14.18.1 | 0.0008 | - |
tropolone | pH 7.2, temperature not specified in the publication | Agaricus bisporus | |
1.14.18.1 | 0.005 | - |
kojic acid | pH 7.2, temperature not specified in the publication | Agaricus bisporus | |
1.14.18.1 | 0.064 | - |
3-hydroxy-1,2-dimethyl-4(1H)-pyridone | pH 7.2, temperature not specified in the publication | Agaricus bisporus | |
1.14.18.1 | 0.145 | - |
5-hydroxy-4-oxo-4H-pyran-2-carboxylic acid | pH 7.2, temperature not specified in the publication | Agaricus bisporus | |
1.14.18.1 | 1 | - |
2-ethyl-3-hydroxy-4H-pyran-4-one | pH 7.2, temperature not specified in the publication | Agaricus bisporus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.14.18.1 | malfunction | excessive accumulation of melanin, due to the overexpression of the enzyme, leads to skin disorders such as age spots, freckles and malignant melanoma | Agaricus bisporus |
1.14.18.1 | physiological function | tyrosinase is a key enzyme in melanin synthesis | Agaricus bisporus |