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Literature summary extracted from

  • Yang, C.; Lim, W.; Bazer, F.W.; Song, G.
    Oleic acid stimulation of motility of human extravillous trophoblast cells is mediated by stearoyl-CoA desaturase-1 activity (2017), Mol. Hum. Reprod., 23, 755-770 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.1 gene SCD, semiquantitative and quantitative RT-PCR enzyme expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Homo sapiens
-
oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Homo sapiens O00767
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 extravillous trophoblast
-
Homo sapiens
-
1.14.19.1 HTR8/SVneo cell EVT cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
Homo sapiens oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD1
-
Homo sapiens
1.14.19.1 stearoyl-CoA desaturase-1
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 cytochrome b5
-
Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.19.1 physiological function oleic acid stimulation of motility of human extravillous trophoblast cells is mediated by stearoyl-CoA desaturase-1 activity. SCD1 is a key enzyme involved in oleic acid-induced migration of HTR8/SVneo cells. Regulatory effects of oleic acid and SCD1 on oxidative stress in HTR8/SVneo cells, effects of oleic acid and elaidic acid on proliferation and migration of HTR8/SVneo cell lines, overview Homo sapiens