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Literature summary extracted from

  • Anand, S.; Rollakanti, K.R.; Brankov, N.; Brash, D.E.; Hasan, T.; Maytin, E.V.
    Fluorouracil enhances photodynamic therapy of squamous cell carcinoma via a p53-independent mechanism that increases protoporphyrin IX levels and tumor cell death (2017), Mol. Cancer Ther., 16, 1092-1101 .
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.3.3.3 medicine the regulation of the enzyme is important in differentiation therapy for cancer treatment Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.3.3 DNA and amino acid sequence determination and analysis, eighteen functional C/EBP binding motifs in the mCPO promoter are found, all are predicted to bind C/EBPs with moderate or higher affinity Homo sapiens
1.3.3.3 DNA and amino acid sequence determination and analysis, the murine CPO gene upstream region contains many competent C/EBP binding sites Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.3.3.3 additional information loss of inducibility due to the promoter mutations occur reproducibly with all C/EBP isoforms, arguing that CPO promoter activity depends upon C/EBP site location, and not simply upon inherent binding affinity, hypothetical modeling, overview Homo sapiens
1.3.3.3 additional information loss of inducibility due to the promoter mutations occur reproducibly with all C/EBP isoforms, arguing that CPO promoter activity depends upon C/EBP site location, and not simply upon inherent binding affinity, hypothetical modeling, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.3.3 cytosol
-
 Homo sapiens 5829
-
1.3.3.3 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ Homo sapiens
-
 protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen III + O2 + 2 H+ Mus musculus
-
 protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.3 Homo sapiens P36551
-
-
1.3.3.3 Mus musculus P36552 nude mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.3.3 A-431 cell
-
 Mus musculus
-
1.3.3.3 LNCaP cell
-
 Homo sapiens
-
1.3.3.3 MEL cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.3 coproporphyrinogen III + O2 + 2 H+
-
 Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?
1.3.3.3 coproporphyrinogen III + O2 + 2 H+
-
 Mus musculus protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.3.3 coproporphyrinogen oxidase
-
 Homo sapiens
1.3.3.3 coproporphyrinogen oxidase
-
 Mus musculus
1.3.3.3 CPO
-
 Homo sapiens
1.3.3.3 CPO
-
 Mus musculus

Expression

EC Number Organism Comment Expression
1.3.3.3 Mus musculus in subcutaneous A431 tumors in mice, pretreatment with vitamin D induces the expression of CCAAT-enhancer binding proteins (C/EBPbeta) isoforms, and of coproporphyrinogen oxidase (CPO). Vitamin D leads to strong accumulation of protoporphyrinogen-IX, PpIX. The murine CPO gene upstream region contains many competent C/EBP binding sites, analysis of C/EBPbeta and enzyme CPO interaction analysis, binding site analysis, overview. All C/EBP sites in murine CPO are asymmetric, with wide divergence between the two half-sites, fifteen functional C/EBP binding motifs in the mCPO promoter are found up
1.3.3.3 Homo sapiens pretreatment with vitamin D induces the expression of CCAAT-enhancer binding proteins (C/EBPbeta) isoforms, and of coproporphyrinogen oxidase (CPO). Vitamin D leads to strong accumulation of protoporphyrinogen-IX, PpIX. When MEL cells are incubated in 1% DMSO, large amounts of porphyrins are produced and under these conditions C/EBPbeta expression is upregulated. Concurrently, CPO expression is increased at both mRNA and protein levels, and higher levels of protoporphyrinogen-IX are generated in response to exogenously added 5-aminolevulic acid. LNCaP carcinoma lines respond to calcitriol with increases in enzyme CPO and protoporphyrinogen-IX levels concurrently. The human CPO gene upstream region contains many competent C/EBP binding sites, analysis of C/EBPbeta and enzyme CPO interaction analysis, binding site analysis, overview. Eighteen functional C/EBP binding motifs in the mCPO promoter are found, all are predicted to bind C/EBPs with moderate or higher affinity up

General Information

EC Number General Information Comment Organism
1.3.3.3 metabolism coproporphyrinogen oxidase (CPO) is an enzyme involved in the heme pathway responsible for the conversion of 5-aminolevulinic acid into protoporphyrin IX, coproporphyrinogen oxidase (CPO) is the sixth enzyme in the cascade Homo sapiens
1.3.3.3 metabolism coproporphyrinogen oxidase (CPO) is an enzyme involved in the heme pathway responsible for the conversion of 5-aminolevulinic acid into protoporphyrin IX, coproporphyrinogen oxidase (CPO) is the sixth enzyme in the cascade Mus musculus
1.3.3.3 physiological function coproporphyrinogen oxidase (CPO) is a rate-limiting enzyme in the heme pathway responsible for the conversion of coproporphyrinogen III into protoporphyrin IX Mus musculus
1.3.3.3 physiological function coproporphyrinogen oxidase (CPO) is a rate-limiting enzyme in the heme pathway responsible for the conversion of coproporphyrinogen III into protoporphyrin IX. The efficacy of photodynamic therapy for epithelial cancers is increased when photodynamic therapy is combined with calcitriol (Vit D), a form of differentiation therapy, underlying mechanism, overview. Differentiation therapy is associated with upregulation of C/EBPs, CPO gene expression, and PpIX production in tumors in vivo. Differentiation-promoting agents are known to upregulate CCAAT-enhancer binding proteins (C/EBPs), powerful regulators of cellular differentiation, and coproporphyrinogen oxidase (CPO). Cooperative interactions between regularly spaced C/EBP sites appear critical for CPO transcriptional regulation by differentiation therapy, mechanistic rationale for DT/PDT combination therapy for cancer Homo sapiens