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Literature summary extracted from

  • Souza, C.F.; Verdi, C.M.; Baldissera, M.D.; Doleski, P.H.; Vizzotto, B.S.; Santos, R.C.V.; Baldisserotto, B.
    Xanthine oxidase activity affects pro-oxidative and pro-inflammatory profiles in spleen of silver catfish experimentally infected with Aeromonas caviae (2017), Microb. Pathog., 113, 25-28 .
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.3.2 Molybdenum in the molybdopterin cofactor Bagrus bajad

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 hypoxanthine + NAD+ + H2O Bagrus bajad
-
 xanthine + NADH + H+
-
 ?
1.17.3.2 xanthine + H2O + O2 Bagrus bajad
-
 urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Bagrus bajad
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 spleen
-
 Bagrus bajad
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 hypoxanthine + NAD+ + H2O
-
 Bagrus bajad xanthine + NADH + H+
-
 ?
1.17.3.2 xanthine + H2O + O2
-
 Bagrus bajad urate + H2O2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.3.2 XOR
-
 Bagrus bajad

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.3.2 molybdopterin
-
 Bagrus bajad
1.17.3.2 NAD+
-
 Bagrus bajad

Expression

EC Number Organism Comment Expression
1.17.3.2 Bagrus bajad the enzyme is upregulated and enzyme activity increases in the spleen of animals infected with Aeromonas caviae, as do the splenic levels of uric acid, reactive oxygen species, and metabolites of nitric oxide (NOx), compared to the uninfected control group up

General Information

EC Number General Information Comment Organism
1.17.3.2 malfunction upregulation of splenic xanthine oxidase activity contributes to disease pathogenesis of Aeromonas caviae infection, as well as whether it may be considered a pathway involved in reactive oxygen species (ROS) and nitric oxide (NO) production. Excessive uric acid induces the release of pro-inflammatory mediators, such as ROS and NOx, which contribute to disease pathophysiology, in spleen tissue they contribute to oxidation and inflammation of the tissue Bagrus bajad
1.17.3.2 physiological function xanthine oxidoreductase (XOR) is a molybdopterin-containing enzyme that catalyzes the oxidation of hypoxanthine to xanthine, and further generates uric acid from xanthine in the purine metabolic pathway Bagrus bajad