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Literature summary extracted from

  • Skupinska, M.; Stepniak, P.; Letowska, I.; Rychlewski, L.; Barciszewska, M.; Barciszewski, J.; Giel-Pietraszuk, M.
    Natural compounds as inhibitors of tyrosyl-tRNA synthetase (2017), Microb. Drug Resist., 23, 308-320 .
    View publication on PubMed

Application

EC Number Application Comment Organism
6.1.1.1 drug development TyrRS enzymes are candidates for therapeutic targets in the prevention and therapy of microbial infections Staphylococcus aureus
6.1.1.1 drug development TyrRS enzymes are candidates for therapeutic targets in the prevention and therapy of microbial infections Escherichia coli
6.1.1.1 drug development TyrRS enzymes are candidates for therapeutic targets in the prevention and therapy of microbial infections Pseudomonas aeruginosa

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.1 acacetin strong inhibition Escherichia coli
6.1.1.1 acacetin strong inhibition Pseudomonas aeruginosa
6.1.1.1 acacetin strong inhibition Staphylococcus aureus
6.1.1.1 chrysin strong inhibition Escherichia coli
6.1.1.1 chrysin strong inhibition Pseudomonas aeruginosa
6.1.1.1 chrysin strong inhibition Staphylococcus aureus
6.1.1.1 epigallocatechin gallate strong inhibition Escherichia coli
6.1.1.1 kaempferide strong inhibition Escherichia coli
6.1.1.1 additional information natural compounds as inhibitors of tyrosyl-tRNA synthetase, effects of various polyphenols, alkaloids, and terpenes-secondary metabolites produced by higher plants, overview. Most of them act as competitive inhibitors. Structure-activity relationship shows that the most potent flavonoid inhibitors contain hydroxyl group at position 5 and 7 of A ring and a -OCH3 group at position 4' of B ring Escherichia coli
6.1.1.1 additional information natural compounds as inhibitors of tyrosyl-tRNA synthetase, effects of various polyphenols, alkaloids, and terpenes-secondary metabolites produced by higher plants, overview. Most of them act as competitive inhibitors. Structure-activity relationship shows that the most potent flavonoid inhibitors contain hydroxyl group at position 5 and 7 of A ring and a -OCH3 group at position 4' of B ring Pseudomonas aeruginosa
6.1.1.1 additional information natural compounds as inhibitors of tyrosyl-tRNA synthetase, effects of various polyphenols, alkaloids, and terpenes-secondary metabolites produced by higher plants, overview. Most of them act as competitive inhibitors. Structure-activity relationship shows that the most potent flavonoid inhibitors contain hydroxyl group at position 5 and 7 of A ring and a -OCH3 group at position 4' of B ring Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.1 Escherichia coli P0AGJ9
-
-
6.1.1.1 Pseudomonas aeruginosa Q9HWP3
-
-
6.1.1.1 Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 Q9HWP3
-
-
6.1.1.1 Staphylococcus aureus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
6.1.1.1 Tyrosyl-tRNA synthetase
-
 Staphylococcus aureus
6.1.1.1 Tyrosyl-tRNA synthetase
-
 Escherichia coli
6.1.1.1 Tyrosyl-tRNA synthetase
-
 Pseudomonas aeruginosa
6.1.1.1 TyrRS
-
 Staphylococcus aureus
6.1.1.1 TyrRS
-
 Escherichia coli
6.1.1.1 TyrRS
-
 Pseudomonas aeruginosa