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Literature summary extracted from

  • Li, Q.; Fan, F.; Gao, X.; Yang, C.; Bi, C.; Tang, J.; Liu, T.; Zhang, X.
    Balanced activation of IspG and IspH to eliminate MEP intermediate accumulation and improve isoprenoids production in Escherichia coli (2017), Metab. Eng., 44, 13-21 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.7.3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin Escherichia coli
-
 (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin
-
 ?
1.17.7.3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin Escherichia coli CAR005
-
 (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.7.3 Escherichia coli
-
-
-
1.17.7.3 Escherichia coli CAR005
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.7.3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin
-
 Escherichia coli (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin
-
 ?
1.17.7.3 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + reduced flavodoxin
-
 Escherichia coli CAR005 (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + oxidized flavodoxin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.7.3 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
-
 Escherichia coli
1.17.7.3 IspG
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.7.3 NADPH
-
 Escherichia coli

General Information

EC Number General Information Comment Organism
1.17.7.3 physiological function enzyme activation leads to significant decrease of cell growth and beta-carotene production Escherichia coli