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Literature summary extracted from

  • Vasilevskaya, A.V.; Yantsevich, A.V.; Sergeev, G.V.; Lemish, A.P.; Usanov, S.A.; Gilep, A.A.
    Identification of Mycobacterium tuberculosis enzyme involved in vitamin D and 7-dehydrocholesterol metabolism (2017), J. Steroid Biochem. Mol. Biol., 169, 202-209 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.14.15.14 Mycobacterium tuberculosis P9WPP3
-
-
1.14.15.14 Mycobacterium tuberculosis H37Rv P9WPP3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.15.14 farnesol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
 Mycobacterium tuberculosis ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
 ?
1.14.15.14 farnesol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
 Mycobacterium tuberculosis H37Rv ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
 ?
1.14.15.14 geraniol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
 Mycobacterium tuberculosis ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
 ?
1.14.15.14 geraniol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
 Mycobacterium tuberculosis H37Rv ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
 ?
1.14.15.14 geranylgeraniol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
 Mycobacterium tuberculosis ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
 ?
1.14.15.14 geranylgeraniol + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
 Mycobacterium tuberculosis H37Rv ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
 ?
1.14.15.14 lauric acid + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
 Mycobacterium tuberculosis ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
 ?
1.14.15.14 lauric acid + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
 Mycobacterium tuberculosis H37Rv ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
 ?
1.14.15.14 additional information the fusion complex of cytochrome b5 and NADH-cytochrome b5 reductase reduces Cyp124 (reduction efficiency -12.9%). The electron transfer pair adrenodoxin/NADPH-adrenodoxin reductase has a similar efficiency for Cyp124 reduction (reduction efficiency -9.4%) as the fusion complex. Rat NADPH-cytochrome P450 reductase is less effective for Cyp124 reduction. The enzyme can oxidize provitamin D3 (7-dehydrocholesterol) and vitamin D3. The final product is different from 1alpha- and 25-hydroxyvitamin D3 Mycobacterium tuberculosis ?
-
 ?
1.14.15.14 additional information the fusion complex of cytochrome b5 and NADH-cytochrome b5 reductase reduces Cyp124 (reduction efficiency -12.9%). The electron transfer pair adrenodoxin/NADPH-adrenodoxin reductase has a similar efficiency for Cyp124 reduction (reduction efficiency -9.4%) as the fusion complex. Rat NADPH-cytochrome P450 reductase is less effective for Cyp124 reduction. The enzyme can oxidize provitamin D3 (7-dehydrocholesterol) and vitamin D3. The final product is different from 1alpha- and 25-hydroxyvitamin D3 Mycobacterium tuberculosis H37Rv ?
-
 ?
1.14.15.14 phytanic acid + O2 + reduced adrenodoxin [iron-sulfur] cluster + H+
-
 Mycobacterium tuberculosis ? + H2O + oxidized adrenodoxin [iron-sulfur] cluster
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.15.14 ? x * 48000, SDS-PAGE Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
1.14.15.14 CYP124
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.15.14 cytochrome P450 six-coordinate, low-spin form of cytochrome P450 with Soret region absorption maximum at 417 nm Mycobacterium tuberculosis