Literature summary extracted from

Wang, J.; Zeng, L.; Zhang, L.; Guo, Z.Z.; Lu, S.F.; Ming, S.L.; Li, G.L.; Wan, B.; Tian, K.G.; Yang, G.Y.; Chu, B.B.
Cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication (2017), J. Gen. Virol., 98, 1467-1476 .

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.14.99.38	H242Q/H243Q	catalytically inactive	Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.99.38	cholesterol + AH2 + O2	Sus scrofa	-	25-hydroxycholesterol + A + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.99.38	Sus scrofa	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.99.38	3D4/21 cell	-	Sus scrofa	-
1.14.99.38	alveolar macrophage	-	Sus scrofa	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.99.38	cholesterol + AH2 + O2	-	Sus scrofa	25-hydroxycholesterol + A + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.99.38	CH25H	-	Sus scrofa

Expression

EC Number	Organism	Comment	Expression
1.14.99.38	Sus scrofa	pseudorabies virus infection of porcine alveolar macrophages is attenuated by enzyme overexpression (24 h post infection)	up

General Information

EC Number	General Information	Comment	Organism
1.14.99.38	physiological function	cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication	Sus scrofa

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Release 2023.1 (January 2023)