Literature summary extracted from

Igbinoba, S.I.; Akanmu, M.A.; Onyeji, C.O.; Soyinka, J.O.; Owolabi, A.R.; Nathaniel, T.I.; Pullela, S.V.; Cook, J.M.
Influence of a Nigerian honey on CYP3A4 biotransformation of quinine in healthy volunteers (2015), J. Clin. Pharm. Ther., 40, 545-549 .

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.14.55	additional information	enzyme activity is not significantly altered following low or high dose of Nigeria honey	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.14.55	quinine + [reduced NADPH-hemoprotein reductase] + O2	Homo sapiens	-	3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.55	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.55	quinine + [reduced NADPH-hemoprotein reductase] + O2	-	Homo sapiens	3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.14.55	CYP3A4	-	Homo sapiens

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Release 2023.1 (January 2023)