Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Dornevil, K.; Davis, I.; Fielding, A.J.; Terrell, J.R.; Ma, L.; Liu, A.
    Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 from Mycobacterium tuberculosis proceeds through a catalytic shunt pathway (2017), J. Biol. Chem., 292, 13645-13657 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + [reduced NADPH-hemoprotein reductase] + O2 Mycobacterium tuberculosis the enzyme is involved in the biosynthesis of mycocyclosin. It is crucial for the viability of this pathogen mycocyclosin + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.70 Mycobacterium tuberculosis P9WPP7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + [reduced NADPH-hemoprotein reductase] + O2 the enzyme is involved in the biosynthesis of mycocyclosin. It is crucial for the viability of this pathogen Mycobacterium tuberculosis mycocyclosin + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + [reduced NADPH-hemoprotein reductase] + O2 study of substrate binding kinetics Mycobacterium tuberculosis mycocyclosin + [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.70 CYP121
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.70 cytochrome P450 a plausible free radical–based mechanisms for the C–C bond coupling reaction is proposed Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
1.14.19.70 metabolism the enzyme is involved in the biosynthesis of mycocyclosin. It is crucial for the viability of this pathogen Mycobacterium tuberculosis