EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.20.4.3 | C19S | inactive | Mycobacterium tuberculosis |
1.20.4.3 | C22S | the mutant displays a slightly higher reducing activity toward mixed disulfides compared to the wild type enzyme | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.20.4.3 | Mycobacterium tuberculosis | O53193 | - |
- |
1.20.4.3 | Mycobacterium tuberculosis H37Rv | O53193 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.20.4.3 | additional information | the enzyme receives electrons through the mycothiol/mycothione reductase/NADPH pathway to activate TP053, preferentially via a dithiol-disulfide mechanism. The enzyme uses a monothiol-disulfide exchange mechanism to reduce S-mycothiolated mixed disulfides and intramolecular disulfides. The enzyme has no oxidase properties | Mycobacterium tuberculosis | ? | - |
? | |
1.20.4.3 | additional information | the enzyme receives electrons through the mycothiol/mycothione reductase/NADPH pathway to activate TP053, preferentially via a dithiol-disulfide mechanism. The enzyme uses a monothiol-disulfide exchange mechanism to reduce S-mycothiolated mixed disulfides and intramolecular disulfides. The enzyme has no oxidase properties | Mycobacterium tuberculosis H37Rv | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.20.4.3 | ? | 2 * 23086, liquid chromatography-mass spectrometry | Mycobacterium tuberculosis |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.20.4.3 | Mrx2 | - |
Mycobacterium tuberculosis |
1.20.4.3 | mycoredoxin-2 | - |
Mycobacterium tuberculosis |
1.20.4.3 | mycothiol-dependent reductase | - |
Mycobacterium tuberculosis |
1.20.4.3 | Rv2466c | - |
Mycobacterium tuberculosis |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.20.4.3 | physiological function | the enzyme is essential for bacterial survival under H2O2 stress | Mycobacterium tuberculosis |