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Literature summary extracted from

  • Dayer, C.; Stamenkovic, I.
    Recruitment of matrix metalloproteinase-9 (MMP-9) to the fibroblast cell surface by lysyl hydroxylase 3 (LH3) triggers transforming growth factor-beta (TGF-beta) activation and fibroblast differentiation (2015), J. Biol. Chem., 290, 13763-13778 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.4 gene PLOD3 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.4 cell surface
-
 Homo sapiens 9986
-
1.14.11.4 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.14.11.4 extracellular the enzyme is secreted Homo sapiens
-
-
1.14.11.4 additional information lysyl hydroxylase 3 is a multifunctional protein that localizes to the endoplasmic reticulum but is also secreted into the extracellular space and is associated with collagenous proteins on the cell surface Homo sapiens
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-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.4 [procollagen]-L-lysine + 2-oxoglutarate + O2 Homo sapiens
-
 [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.4 Homo sapiens O60568
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.4 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.4 [procollagen]-L-lysine + 2-oxoglutarate + O2
-
 Homo sapiens [procollagen]-(2S,5R)-5-hydroxy-L-lysine + succinate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.4 LH3
-
 Homo sapiens
1.14.11.4 lysyl hydroxylase 3
-
 Homo sapiens
1.14.11.4 PLOD3
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.11.4 malfunction enzyme LH3 downregulation decreases MMP-9 recruitment to MRC-5 and thus MMP-9/LH3 interaction Homo sapiens
1.14.11.4 physiological function recruitment of matrix metalloproteinase-9 (MMP-9) to the fibroblast cell surface by lysyl hydroxylase 3 triggers transforming growth factor-beta (TGF-beta) activation and fibroblast differentiation. LH3 provides the docking mechanism for MMP-9 cell surface association via the MMP-9 FN domain. Recruitment of MMP-9 to fibroblast cell surface does not depend merely on LH3 expression at the cell membrane. LH3 provides a mechanism for deployment of MMP-9 catalytic activity at the fibroblast cell surface that promotes TGF-beta activation and the corresponding enhancement of alpha-SMA expression. MMP-9-induced TGF-beta activation promotes alpha-SMA expression in fibroblasts is consistent with a function that supports tumor progression. LH3 expressed in a variety of tumor cell types fails to recruit MMP-9 to their cell surface Homo sapiens