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Literature summary extracted from

  • Libiad, M.; Yadav, P.; Vitvitsky, V.; Martinov, M.; Banerjee, R.
    Organization of the human mitochondrial hydrogen sulfide oxidation pathway (2014), J. Biol. Chem., 289, 30901-30910 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.5.8 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.5.8 0.005
-
 Sulfide with cysteine as acceptor, at pH 7.4 and 37°C Homo sapiens
1.8.5.8 0.007
-
 Sulfide with homocysteine as acceptor, at pH 7.4 and 37°C Homo sapiens
1.8.5.8 0.01
-
 Sulfide with glutathione as acceptor, at pH 7.4 and 37°C Homo sapiens
1.8.5.8 0.13
-
 Sulfide with sulfite as acceptor, at pH 7.4 and 37°C Homo sapiens
1.8.5.8 0.22
-
 sulfite at pH 7.4 and 37°C Homo sapiens
1.8.5.8 0.32
-
 Sulfide at pH 7.4 and 37°C Homo sapiens
1.8.5.8 2 3 cysteine at pH 7.4 and 37°C Homo sapiens
1.8.5.8 22
-
 glutathione at pH 7.4 and 37°C Homo sapiens
1.8.5.8 22
-
 homocysteine at pH 7.4 and 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.5.8 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.8.5.8 Homo sapiens Q9Y6N5
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.5.8 Ni-NTA agarose column chromatography and Mono Q column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.5.8 hydrogen sulfide + cysteine + coenzyme Q1
-
 Homo sapiens ?
-
 ?
1.8.5.8 hydrogen sulfide + glutathione + coenzyme Q1
-
 Homo sapiens S-sulfanylglutathione + reduced coenzyme Q1
-
 ?
1.8.5.8 hydrogen sulfide + homocysteine + coenzyme Q1
-
 Homo sapiens ?
-
 ?
1.8.5.8 hydrogen sulfide + sulfide + coenzyme Q1
-
 Homo sapiens ?
-
 ?
1.8.5.8 hydrogen sulfide + sulfite + coenzyme Q1
-
 Homo sapiens thiosulfate + reduced coenzyme Q1
-
 ?
1.8.5.8 additional information no activity with DHLA, cysteamine, coenzyme A, hypotaurine, cysteine sulfinic acid, and thioredoxin Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.8.5.8 ? x * 48000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.8.5.8 SQR
-
 Homo sapiens
1.8.5.8 sulfide quinone oxidoreductase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8.5.8 74
-
 Sulfide with homocysteine as acceptor, at pH 7.4 and 37°C Homo sapiens
1.8.5.8 92
-
 Sulfide with cysteine as acceptor, at pH 7.4 and 37°C Homo sapiens
1.8.5.8 94
-
 Sulfide with glutathione as acceptor, at pH 7.4 and 37°C Homo sapiens
1.8.5.8 113
-
 Sulfide with sulfite as acceptor, at pH 7.4 and 37°C Homo sapiens
1.8.5.8 373
-
 Sulfide at pH 7.4 and 37°C Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.8.5.8 4.1
-
 cysteine at pH 7.4 and 37°C Homo sapiens
1.8.5.8 4.2
-
 homocysteine at pH 7.4 and 37°C Homo sapiens
1.8.5.8 5.1
-
 glutathione at pH 7.4 and 37°C Homo sapiens
1.8.5.8 23.1
-
 Sulfide at pH 7.4 and 37°C Homo sapiens
1.8.5.8 1700
-
 sulfite at pH 7.4 and 37°C Homo sapiens
1.8.5.8 11000
-
 Sulfide with glutathione as acceptor, at pH 7.4 and 37°C Homo sapiens
1.8.5.8 13000
-
 Sulfide with homocysteine as acceptor, at pH 7.4 and 37°C Homo sapiens
1.8.5.8 19000
-
 Sulfide with cysteine as acceptor, at pH 7.4 and 37°C Homo sapiens
1.8.5.8 29000
-
 Sulfide with sulfite as acceptor, at pH 7.4 and 37°C Homo sapiens