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Literature summary extracted from

  • Zhou, J.J.; Wang, F.; Xu, Z.; Lo, W.S.; Lau, C.F.; Chiang, K.P.; Nangle, L.A.; Ashlock, M.A.; Mendlein, J.D.; Yang, X.L.; Zhang, M.; Schimmel, P.
    Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis (2014), J. Biol. Chem., 289, 19269-19275 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.1.1.21 expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.1.1.21 cytoplasm
-
 Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.21 ATP + L-histidine + tRNAHis Homo sapiens
-
 AMP + diphosphate + L-histidyl-tRNAHis
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.21 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.1.1.21 Ni-NTA column chromatography and Superdex 200 gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.21 adipose tissue
-
 Homo sapiens
-
6.1.1.21 bone marrow
-
 Homo sapiens
-
6.1.1.21 colon
-
 Homo sapiens
-
6.1.1.21 heart
-
 Homo sapiens
-
6.1.1.21 kidney
-
 Homo sapiens
-
6.1.1.21 leukocyte
-
 Homo sapiens
-
6.1.1.21 liver
-
 Homo sapiens
-
6.1.1.21 lung
-
 Homo sapiens
-
6.1.1.21 pancreas
-
 Homo sapiens
-
6.1.1.21 skeletal muscle
-
 Homo sapiens
-
6.1.1.21 small intestine
-
 Homo sapiens
-
6.1.1.21 spleen
-
 Homo sapiens
-
6.1.1.21 thyroid gland
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.21 ATP + L-histidine + tRNAHis
-
 Homo sapiens AMP + diphosphate + L-histidyl-tRNAHis
-
 ?

Subunits

EC Number Subunits Comment Organism
6.1.1.21 ? x * 55000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
6.1.1.21 HARS
-
 Homo sapiens
6.1.1.21 HisRS
-
 Homo sapiens
6.1.1.21 Histidyl-tRNA synthetase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.21 ATP
-
 Homo sapiens