Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sadler, J.E.; Rearick, J.I.; Paulson, J.C.; Hill, R.L.
    Purification to homogeneity of a beta-galactoside alpha2 leads to 3 sialyltransferase and partial purification of an alpha-N-acetylgalactosaminide alpha2 leads to 6 sialyltransferase from porcine submaxillary glands (1979), J. Biol. Chem., 254, 4434-4443 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.3.4 CDP less effective than CTP Sus scrofa
2.4.3.4 CMP less effective than CTP Sus scrofa
2.4.3.4 CTP most potent inhibitor among cytidine nucleotides Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.4 membrane
-
 Sus scrofa 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.3.4 50000
-
 gel filtration, enzyme form A and B Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.4 Sus scrofa Q02745
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.3.4
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.4 submandibular gland
-
 Sus scrofa
-

Storage Stability

EC Number Storage Stability Organism
2.4.3.4 -20°C, 50% (w/v) glycerol, 6 months, no loss of activity Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.4 CMP-N-acetyl-beta-neuraminate + [porcine submaxillary asialo-mucin]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
-
 Sus scrofa CMP + [porcine submaxillary asialo-mucin]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-serine
-
 ?
2.4.3.4 CMP-N-acetyl-beta-neuraminate + [porcine submaxillary asialo-mucin]-(O-3-(beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
-
 Sus scrofa CMP + [porcine submaxillary asialo-mucin]-(O-3-(alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-alpha-D-GalNAc-(1->)))-L-threonine
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.3.4 0.00022
-
 CTP pH and temperature not specified in the publication Sus scrofa

General Information

EC Number General Information Comment Organism
2.4.3.4 metabolism the enzyme is involved in biosynthesis of O-linked oligosaccharide chains of glycoproteins Sus scrofa