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Literature summary extracted from

  • Yoshimura, Y.; Araki, A.; Maruta, H.; Takahashi, Y.; Yamashita, H.
    Molecular cloning of rat acss3 and characterization of mammalian propionyl-CoA synthetase in the liver mitochondrial matrix (2017), J. Biochem., 161, 279-289 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.17 expressed in Escherichia coli, HeLa cells, and Hep-G2 cells Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.2.1.17 0.19
-
 propanoate at pH 8.0 and 37°C Rattus norvegicus
6.2.1.17 3.7
-
 Butyrate at pH 8.0 and 37°C Rattus norvegicus
6.2.1.17 5.4
-
 acetate at pH 8.0 and 37°C Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.17 mitochondrion mitochondrial matrix Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.17 ATP + propanoate + CoA Rattus norvegicus
-
 AMP + diphosphate + propanoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.17 Rattus norvegicus A0A0G2K047
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.17 kidney
-
 Rattus norvegicus
-
6.2.1.17 liver highest expression Rattus norvegicus
-
6.2.1.17 soleus muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.17 ATP + acetate + CoA
-
 Rattus norvegicus AMP + diphosphate + acetyl-CoA
-
 ?
6.2.1.17 ATP + butyrate + CoA
-
 Rattus norvegicus AMP + diphosphate + butyryl-CoA
-
 ?
6.2.1.17 ATP + propanoate + CoA
-
 Rattus norvegicus AMP + diphosphate + propanoyl-CoA
-
 ?
6.2.1.17 additional information no enzyme activity is detected using fatty acids with 5-8 carbon chains or 3-hydroxybutyrate as substrates Rattus norvegicus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
6.2.1.17 ? x * 72000, SDS-PAGE Rattus norvegicus
6.2.1.17 ? x * 74700, calculated from amino acid sequence Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
6.2.1.17 ACSS3
-
 Rattus norvegicus
6.2.1.17 Propionyl-CoA synthetase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.17 ATP
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
6.2.1.17 Rattus norvegicus enzyme expression and activity are significantly increased by fasting up