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Literature summary extracted from
- Structure-activity relationship study of hydroxycoumarins and mushroom tyrosinase (2015), J. Agric. Food Chem., 63, 7236-7244 .
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.18.1 | 3-hydroxycoumarin | - |
Agaricus bisporus |  |
| 1.14.18.1 | 4-Hydroxycoumarin | weak inhibition | Agaricus bisporus | |
| 1.14.18.1 | 6-hydroxycoumarin | weak inhibition | Agaricus bisporus | |
| 1.14.18.1 | 7-hydroxycoumarin | - |
Agaricus bisporus | |
| 1.14.18.1 | esculetin | 6,7-dihydroxycoumarin, weak inhibition | Agaricus bisporus | |
| 1.14.18.1 | additional information | hydroxycoumarin derivatives as enzyme inhibitors, molecular docking study, structure-activity relationships, overview | Agaricus bisporus | |
| 1.14.18.1 | tropolone | - |
Agaricus bisporus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.1 | 2 L-dopa + O2 | Agaricus bisporus | - |
2 dopaquinone + 2 H2O | - |
? | |
| 1.14.18.1 | tyrosine + O2 | Agaricus bisporus | - |
dopaquinone + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | Agaricus bisporus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.18.1 | commercial preparation | - |
Agaricus bisporus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.18.1 | 2 L-dopa + O2 | - |
Agaricus bisporus | 2 dopaquinone + 2 H2O | - |
? | |
| 1.14.18.1 | tyrosine + O2 | - |
Agaricus bisporus | dopaquinone + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.18.1 | mushroom tyrosinase | - |
Agaricus bisporus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | 25 | - |
assay at | Agaricus bisporus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.18.1 | 6.5 | - |
assay at | Agaricus bisporus |
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Release 2023.1 (January 2023)
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