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Literature summary extracted from

  • Ortiz-Ruiz, C.V.; Ballesta de Los Santos, M.; Berna, J.; Fenoll, J.; Garcia-Ruiz, P.A.; Tudela, J.; Garcia-Canovas, F.
    Kinetic characterization of oxyresveratrol as a tyrosinase substrate (2015), IUBMB Life, 67, 828-836 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 4-hydroxyanisole can also act as enzyme substrate Agaricus bisporus
1.14.18.1 oxyresveratrol a stilbenoid and reversible, non-competitive, and strong inhibitor of tyrosinase, is proposed as skin-whitening and anti-browning agent, can also act as enzyme substrate Agaricus bisporus
1.14.18.1 resveratrol can also act as enzyme substrate Agaricus bisporus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.18.1 additional information
-
additional information Michaelis-Menten kinetics Agaricus bisporus
1.14.18.1 0.00865
-
oxyresveratrol pH 7.0, 25°C Agaricus bisporus
1.14.18.1 0.08
-
4-hydroxyanisole pH 7.0, 25°C Agaricus bisporus
1.14.18.1 0.21
-
L-tyrosine pH 7.0, 25°C Agaricus bisporus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.1 Cu2+ a copper-containing enzyme Agaricus bisporus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.1 L-tyrosine + O2 Agaricus bisporus
-
dopaquinone + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
Agaricus bisporus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 4-hydroxyanisole + O2
-
Agaricus bisporus ?
-
?
1.14.18.1 L-tyrosine + O2
-
Agaricus bisporus dopaquinone + H2O
-
?
1.14.18.1 oxyresveratrol + O2 tyrosinase hydroxylates the oxyresveratrol to an o-diphenol and oxidizes the latter to an o-quinone, which finally isomerizes to p-quinone. For these reactions to take place the presence of the Eox (oxy-tyrosinase) form is necessary, analysis of the catalytic mechanism, overview. The compound can also act as inhibitor of tyrosinase Agaricus bisporus ?
-
?
1.14.18.1 resveratrol + O2
-
Agaricus bisporus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 mushroom tyrosinase
-
Agaricus bisporus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.18.1 25
-
assay at Agaricus bisporus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.18.1 5.39
-
oxyresveratrol pH 7.0, 25°C Agaricus bisporus
1.14.18.1 7.9
-
L-tyrosine pH 7.0, 25°C Agaricus bisporus
1.14.18.1 184.2
-
4-hydroxyanisole pH 7.0, 25°C Agaricus bisporus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.18.1 7
-
assay at Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 additional information
-
additional information inhibition kinetics Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.0012
-
pH 7.0, 25°C Agaricus bisporus oxyresveratrol

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.14.18.1 33
-
L-tyrosine pH 7.0, 25°C Agaricus bisporus
1.14.18.1 620
-
oxyresveratrol pH 7.0, 25°C Agaricus bisporus
1.14.18.1 2300
-
4-hydroxyanisole pH 7.0, 25°C Agaricus bisporus