Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rasheed, Z.; Alzolibani, A.A.; Al-Shobaili, H.A.; Saif, G.B.; Al Robaee, A.A.
    Biochemical and immunological studies on erythrocytes superoxide dismutase modified by nitric oxide in patients with alopecia areata implications in alopecia patchy persistent and alopecia universalis (2014), Immunol. Lett., 160, 50-57 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.15.1.1 additional information NO-induced damage in eSOD causes alteration in hydrophobic or aromatic amino acids and protein carbonyl contents Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Cu2+ a Cu/Zn-SOD Homo sapiens
1.15.1.1 Zn2+ a Cu/Zn-SOD Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 2 superoxide + 2 H+ Homo sapiens
-
 O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Homo sapiens P00441
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.15.1.1 erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 2 superoxide + 2 H+
-
 Homo sapiens O2 + H2O2
-
 ?
1.15.1.1 additional information the enzyme activity is detected by its ability to inhibit the autoxidation of epinephrine at pH 10.2 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 erythrocyte superoxide dismutase
-
 Homo sapiens
1.15.1.1 eSOD
-
 Homo sapiens
1.15.1.1 SOD
-
 Homo sapiens
1.15.1.1 SOD1
-
 Homo sapiens
1.15.1.1 superoxide dismutase [Cu-Zn] UniProt Homo sapiens

General Information

EC Number General Information Comment Organism
1.15.1.1 malfunction Role of nitric oxide (NO) modified erythrocytes superoxide dismutase (eSOD) in alopecia areata, a non-scarring hair loss disorder. dysfunctioning of SODis reported in patients with alopecia areata. Protein-A purified IgG of alopecia areata patients (AA-IgG) show strong binding to NO-eSOD in comparison with IgG from controls. In addition, AA-IgG from patients with alopecia universalis recognize NO-eSOD in a greater extentas compared to AA-IgG from patients with patchy persistent alopecia areata. Alopecia universalis patients' sera contain higher levels of NO or carbonyl contents and lower levels of SOD activity compared with patchy persistent alopecia areata patient or control sera Homo sapiens
1.15.1.1 additional information NO-induced damage in eSOD causes alteration in hydrophobic or aromatic amino acids and protein carbonyl contents Homo sapiens
1.15.1.1 physiological function superoxide dismutase (SOD) is a prime antioxidant enzymethat destroys the effects of superoxide, thus limiting the dele-terious effects of reactive oxygen and nitrogen species. SOD is considered an important regulator of oxida-tive/nitrosative stress Homo sapiens