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Literature summary extracted from

  • Anggakusuma, G.; Romero-Brey, I.; Berger, C.; Colpitts, C.C.; Boldanova, T.; Engelmann, M.; Todt, D.; Perin, P.M.; Behrendt, P.; Vondran, F.W.; Xu, S.; Goffinet, C.; Schang, L.M.; Heim, M.H.; Bartenschlager, R.; Pietschmann, T.; Steinmann, E.
    Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation (2015), Hepatology, 62, 702-714 .
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.99.38 cholesterol + AH2 + O2 Homo sapiens
-
25-hydroxycholesterol + A + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.99.38 Homo sapiens Q95992
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.99.38 hepatocyte
-
Homo sapiens
-
1.14.99.38 hepatoma cell
-
Homo sapiens
-
1.14.99.38 liver
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.99.38 cholesterol + AH2 + O2
-
Homo sapiens 25-hydroxycholesterol + A + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.99.38 CH25H
-
Homo sapiens
1.14.99.38 cholesterol-25-hydroxylase
-
Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.99.38 Homo sapiens the enzyme expression in primary human hepatocytes is primarily and transiently induced by type I interferon. Infection with hepatitis C virus causes up-regulation of the enzyme in vivo up

General Information

EC Number General Information Comment Organism
1.14.99.38 physiological function enzyme expression in human hepatoma cells restricts hepatitis C virus infection in a genotype-independent manner Homo sapiens