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Literature summary extracted from

  • Kono, M.; Ohyama, Y.; Lee, Y.C.; Hamamoto, T.; Kojima, N.; Tsuji, S.
    Mouse beta-galactoside alpha2,3-sialyltransferases comparison of in vitro substrate specificities and tissue specific expression (1997), Glycobiology, 7, 469-479 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.3.2 expressed in COS-7 cells as a recombinant enzyme fused with protein A Mus musculus
2.4.3.6 expressed in COS-7 cells as a recombinant enzyme fused with protein A Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.3.2 0.051
-
 beta-D-Gal-(1->3)-beta-D-GalNAc pH 6.4, 37°C Mus musculus
2.4.3.2 0.16
-
 beta-D-Gal-(1->3)-beta-D-GalNAc pH 6.4, 37°C Mus musculus
2.4.3.2 0.75
-
 beta-D-Gal-(1->3)-beta-D-GlcNAc pH 6.4, 37°C Mus musculus
2.4.3.2 2.2
-
 beta-D-Gal-(1->3)-beta-D-GalNAc pH 6.4, 37°C Mus musculus
2.4.3.2 2.3
-
 beta-D-Gal-(1->3)-beta-D-GlcNAc pH 6.4, 37°C Mus musculus
2.4.3.2 3
-
 beta-D-Gal-(1->3)-beta-D-GalNAc pH 6.4, 37°C Mus musculus
2.4.3.2 3.2
-
 beta-D-Gal-(1->3)-beta-D-GlcNAc pH 6.4, 37°C Mus musculus
2.4.3.6 0.22
-
 beta-D-Gal-(1->4)-beta-D-GlcNAc pH 6.4, 37°C Mus musculus
2.4.3.6 0.75
-
 beta-D-Gal-(1->3)-beta-D-GlcNAc pH 6.4, 37°C Mus musculus
2.4.3.6 3
-
 beta-D-Gal-(1->4)-beta-D-GlcNAc pH 6.4, 37°C Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.2 Mus musculus P54751
-
-
2.4.3.2 Mus musculus P97325
-
-
2.4.3.2 Mus musculus Q11204
-
-
2.4.3.2 Mus musculus Q91Y74
-
-
2.4.3.6 Mus musculus P97325
-
-
2.4.3.6 Mus musculus Q91Y74
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.2 brain
-
 Mus musculus
-
2.4.3.2 brain weak expression Mus musculus
-
2.4.3.2 brain strongly expressed Mus musculus
-
2.4.3.2 colon
-
 Mus musculus
-
2.4.3.2 colon weakly expressed Mus musculus
-
2.4.3.2 heart
-
 Mus musculus
-
2.4.3.2 heart weak expression Mus musculus
-
2.4.3.2 kidney
-
 Mus musculus
-
2.4.3.2 kidney weak expression Mus musculus
-
2.4.3.2 liver
-
 Mus musculus
-
2.4.3.2 liver weak expression Mus musculus
-
2.4.3.2 salivary gland weakly expressed Mus musculus
-
2.4.3.2 salivary gland strong expression Mus musculus
-
2.4.3.2 spleen
-
 Mus musculus
-
2.4.3.2 spleen strong expression Mus musculus
-
2.4.3.2 testis weakly expressed Mus musculus
-
2.4.3.2 testis weak expression Mus musculus
-
2.4.3.2 thymus
-
 Mus musculus
-
2.4.3.2 thymus weakly expressed Mus musculus
-
2.4.3.2 thymus weak expression Mus musculus
-
2.4.3.6 brain
-
 Mus musculus
-
2.4.3.6 colon
-
 Mus musculus
-
2.4.3.6 heart
-
 Mus musculus
-
2.4.3.6 kidney
-
 Mus musculus
-
2.4.3.6 liver
-
 Mus musculus
-
2.4.3.6 spleen
-
 Mus musculus
-
2.4.3.6 testis weak expression Mus musculus
-
2.4.3.6 thymus
-
 Mus musculus
-
2.4.3.6 thymus weak expression Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.2 CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GalNAc relative Vmax for ST3Gal IV is 2:5:1 for beta-D-Gal-(1->3)-beta-D-GlcNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc and beta-D-Gal-(1->3)-beta-D-GalNAc, respectively Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
-
 ?
2.4.3.2 CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GalNAc relative Vmax is 4:2:1 for beta-D-Gal-(1->3)-beta-D-GlcNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc and beta-D-Gal-(1->3)-beta-D-GalNAc, respectively Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
-
 ?
2.4.3.2 CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GalNAc Vmax is 10fold higher with beta-D-Gal-(1->3)-beta-D-GalNAc than with beta-D-Gal-(1->3)-beta-D-GlcNAc as substrate Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
-
 ?
2.4.3.2 CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GalNAc Vmax is 4fold higher with beta-D-Gal-(1->3)-beta-D-GalNAc than with beta-D-Gal-(1->3)-beta-D-GlcNAc as substrate Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc
-
 ?
2.4.3.2 CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GlcNAc relative Vmax for ST3Gal IV is 2:5:1 for beta-D-Gal-(1->3)-beta-D-GlcNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc and beta-D-Gal-(1->3)-beta-D-GalNAc, respectively Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc
-
 ?
2.4.3.2 CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GlcNAc Vmax is 10fold higher with beta-D-Gal-(1->3)-beta-D-GalNAc than with beta-D-Gal-(1->3)-beta-D-GlcNAc as substrate Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc
-
 ?
2.4.3.2 CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GlcNAc Vmax is 4fold higher with beta-D-Gal-(1->3)-beta-D-GalNAc than with beta-D-Gal-(1->3)-beta-D-GlcNAc as substrate Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc
-
 ?
2.4.3.6 CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->3)-beta-D-GlcNAc relative Vmax for ST3Gal IV is 2:5:1 for beta-D-Gal-(1->3)-beta-D-GlcNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc and beta-D-Gal-(1->3)-beta-D-GalNAc, respectively Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GlcNAc
-
 ?
2.4.3.6 CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->4)-beta-D-GlcNAc relative Vmax for ST3Gal IV is 2:5:1 for beta-D-Gal-(1->3)-beta-D-GlcNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc and beta-D-Gal-(1->3)-beta-D-GalNAc, respectively Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc
-
 ?
2.4.3.6 CMP-N-acetyl-beta-neuraminate + beta-D-Gal-(1->4)-beta-D-GlcNAc relative Vmax for ST3Gal III is 4:2:1 for beta-D-Gal-(1->3)-beta-D-GlcNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc and beta-D-Gal-(1->3)-beta-D-GalNAc as substrate, respectively Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.2 ST3Gal I
-
 Mus musculus
2.4.3.2 ST3Gal II
-
 Mus musculus
2.4.3.2 ST3Gal III
-
 Mus musculus
2.4.3.2 ST3Gal IV
-
 Mus musculus
2.4.3.6 ST3Gal III
-
 Mus musculus
2.4.3.6 ST3Gal IV
-
 Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.3.2 6.4
-
-
 Mus musculus
2.4.3.6 6.4
-
-
 Mus musculus