BRENDA - Enzyme Database

Overexpression and suppression of Artemisia annua 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1 gene (AaHDR1) differentially regulate artemisinin and terpenoid biosynthesis

Ma, D.; Li, G.; Zhu, Y.; Xie, D.; Front. Plant Sci. 8, doi: 10.3389/fpls.2017.00077 (2017)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.17.7.4
chloroplast
-
Artemisia annua
9507
-
1.17.7.4
plastid
-
Artemisia annua
9536
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.17.7.4
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
Artemisia annua
-
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
1.17.7.4
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
Artemisia annua
-
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.17.7.4
Artemisia annua
A0A1V0C086
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.7.4
flower
-
Artemisia annua
-
1.17.7.4
leaf
highest expression
Artemisia annua
-
1.17.7.4
root
-
Artemisia annua
-
1.17.7.4
stem
-
Artemisia annua
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.7.4
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
-
745010
Artemisia annua
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
1.17.7.4
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
-
745010
Artemisia annua
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
1.17.7.4
?
x * 51405, calculated from amino acid sequence
Artemisia annua
pI Value
EC Number
Organism
Commentary
pI Value Maximum
pI Value
1.17.7.4
Artemisia annua
calculated from amino acid sequence
-
5.6
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.17.7.4
chloroplast
-
Artemisia annua
9507
-
1.17.7.4
plastid
-
Artemisia annua
9536
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.17.7.4
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
Artemisia annua
-
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
1.17.7.4
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
Artemisia annua
-
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.17.7.4
flower
-
Artemisia annua
-
1.17.7.4
leaf
highest expression
Artemisia annua
-
1.17.7.4
root
-
Artemisia annua
-
1.17.7.4
stem
-
Artemisia annua
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.17.7.4
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
-
745010
Artemisia annua
dimethylallyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
1.17.7.4
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + reduced ferredoxin [iron-sulfur] cluster + H+
-
745010
Artemisia annua
isopentenyl diphosphate + oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
1.17.7.4
?
x * 51405, calculated from amino acid sequence
Artemisia annua
pI Value (protein specific)
EC Number
Organism
Commentary
pI Value Maximum
pI Value
1.17.7.4
Artemisia annua
calculated from amino acid sequence
-
5.6
General Information
EC Number
General Information
Commentary
Organism
1.17.7.4
metabolism
enzyme overexpression leads to the increase of artemisinin production
Artemisia annua
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.17.7.4
metabolism
enzyme overexpression leads to the increase of artemisinin production
Artemisia annua