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Literature summary extracted from

  • Jedlicka, P.; Ernst, U.; Votavova, A.; Hanus, R.; Valterova, I.
    Gene expression dynamics in major endocrine regulatory pathways along the transition from solitary to social life in a bumblebee, Bombus terrestris (2016), Front. Physiol., 7, 574 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.127 gene MFE, quantitative RT-PCR enzyme expression analysis Bombus terrestris terrestris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.127 methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2 Bombus terrestris terrestris
-
 juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.127 Bombus terrestris terrestris
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.127 brain
-
 Bombus terrestris terrestris
-
1.14.14.127 crop
-
 Bombus terrestris terrestris
-
1.14.14.127 fat body
-
 Bombus terrestris terrestris
-
1.14.14.127 flight muscle
-
 Bombus terrestris terrestris
-
1.14.14.127 gonad
-
 Bombus terrestris terrestris
-
1.14.14.127 labial gland
-
 Bombus terrestris terrestris
-
1.14.14.127 additional information expression analysis of tissue-specific relative expression levels methyl farnesoate epoxidase (MFE) across castes of Bombus terrestris, overview Bombus terrestris terrestris
-
1.14.14.127 ovary of workers and reproducing queens, high MFE expression in ovaries of bumblebee females Bombus terrestris terrestris
-
1.14.14.127 rectum
-
 Bombus terrestris terrestris
-
1.14.14.127 ventriculus
-
 Bombus terrestris terrestris
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.127 methyl (2E,6E)-farnesoate + [reduced NADPH-hemoprotein reductase] + O2
-
 Bombus terrestris terrestris juvenile hormone III + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.127 MFE
-
 Bombus terrestris terrestris

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.127 NADPH-hemoprotein reductase A flavoprotein containing both FMN and FAD. This enzyme catalyses the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P-450 monooxygenases, EC 1.14.14._ Bombus terrestris terrestris

General Information

EC Number General Information Comment Organism
1.14.14.127 metabolism the enzyme catalyzes the final step of juvenile hormone III biosynthesis Bombus terrestris terrestris
1.14.14.127 physiological function the methyl farnesoate epoxidase gene (MFE) is an indicator of juvenile hormone production. Virgin queens are distinguished by higher expression of forkhead box protein O and downregulated insulin-like peptides and juvenile hormone signaling, indicated by low expression of methyl farnesoate epoxidase (MFE) and transcription factor Krüppel homolog 1 (Kr-h1), while reproducing queens reveal an upregulation of MFE and vitellogenin together with insulin signaling. Workers exhibit an expression pattern of MFE and vitellogenin similar to that of reproducing queens. Males aere characterized by high Kr-h1expression and low vitellogenin level Bombus terrestris terrestris