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Literature summary extracted from

  • Fernandez, I.; Vijayakumar, P.; Marques, C.; Cancela, M.L.; Gavaia, P.J.; Laize, V.
    Zebrafish vitamin K epoxide reductases expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure (2015), Fish Physiol. Biochem., 41, 745-759 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.4 warfarin
-
 Danio rerio

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.4 Danio rerio E7F6X2 vitamin K epoxide reductase complex subunit 1 (Vkorc1)
-
1.17.4.4 Danio rerio Q502B2 vitamin K epoxide reductase complex subunit 1-like 1 (Vkorc1l1)
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.4 brain highest expression in muscle and brain Danio rerio
-
1.17.4.4 eye intermediate expression level Danio rerio
-
1.17.4.4 eye intermediate level of expresssion Danio rerio
-
1.17.4.4 gill low expression level Danio rerio
-
1.17.4.4 liver intermediate expression level Danio rerio
-
1.17.4.4 muscle highest expression in muscle and brain Danio rerio
-
1.17.4.4 ovary highly expressed Danio rerio
-
1.17.4.4 skin low expression level Danio rerio
-
1.17.4.4 spleen intermediate level of expresssion Danio rerio
-
1.17.4.4 stomach low level of expression Danio rerio
-
1.17.4.4 vertebra intermediate expression level Danio rerio
-
1.17.4.4 vertebra intermediate level of expresssion Danio rerio
-

Expression

EC Number Organism Comment Expression
1.17.4.4 Danio rerio level of vkorc1l1 expression is the highest at 4-cell stage, diminishing at Prim-5 stage and remaining stable afterward down
1.17.4.4 Danio rerio level of vkorc1l1 expression is the highest at 4-cell stage, diminishing at Prim-5 stage and remaining stable afterward. Significantly overexpressed in differentiating cells (T1M) but not in mineralizating (T3M) cells up
1.17.4.4 Danio rerio Vkorc1 is detected at 4-cell stage but shows an expression peak at 72-96 h post fertilization, and a lower and stable gene expression value afterward. Significantly overexpressed in differentiating (T1M) but not in mineralizating (T3M) cells up