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Literature summary extracted from

  • Ding, J.; Holzwarth, G.; Penner, M.H.; Patton-Vogt, J.; Bakalinsky, A.T.
    Overexpression of acetyl-CoA synthetase in Saccharomyces cerevisiae increases acetic acid tolerance (2015), FEMS Microbiol. Lett., 362, 1-7 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.6 expressed in Escherichia coli DELTAgloABC cells Salmonella enterica

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.2.6 Cu2+
-
Salmonella enterica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.2.6 0.5
-
S-D-lactoylglutathione at pH 7.5 and 30°C Salmonella enterica

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.2.6 additional information the enzyme is almost unaffected by Mn2+, Mg2+, Ni2+, Fe2+ or Fe3+ Salmonella enterica
3.1.2.6 Zn2+ stimulates activity Salmonella enterica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.1 ATP + acetate + CoA Saccharomyces cerevisiae
-
AMP + diphosphate + acetyl-CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.6 Salmonella enterica
-
serovar typhimurium
-
6.2.1.1 Saccharomyces cerevisiae P52910
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.2.6 Ni-NTA column chromatography and Superdex 200 gel filtration Salmonella enterica

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.6 S-D-lactoylglutathione + H2O
-
Salmonella enterica D-lactate + glutathione
-
?
6.2.1.1 ATP + acetate + CoA
-
Saccharomyces cerevisiae AMP + diphosphate + acetyl-CoA
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.2.6 gloC
-
Salmonella enterica
3.1.2.6 GlxII
-
Salmonella enterica
3.1.2.6 GlxII-2 isoenzyme Salmonella enterica
3.1.2.6 type II glyoxalase
-
Salmonella enterica
3.1.2.6 YcbL
-
Salmonella enterica
6.2.1.1 Acetyl-CoA synthetase
-
Saccharomyces cerevisiae
6.2.1.1 acetyl-coenzyme A synthetase
-
Saccharomyces cerevisiae
6.2.1.1 ACS2
-
Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.1.2.6 0.9
-
S-D-lactoylglutathione at pH 7.5 and 30°C Salmonella enterica

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.1 ATP
-
Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
6.2.1.1 physiological function enzyme overexpression results in higher resistance to acetic acid as measured by an increased growth rate and shorter lag phase relative to a wild type strain, suggesting that enzyme-mediated consumption of acetic acid during fermentation contributes to acetic acid detoxification Saccharomyces cerevisiae

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.1.2.6 1.8
-
S-D-lactoylglutathione at pH 7.5 and 30°C Salmonella enterica