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Literature summary extracted from

  • Kramlinger, V.; Nagy, L.; Fujiwara, R.; Johnson, K.; Phan, T.; Xiao, Y.; Enright, J.; Toomey, M.; Corbo, J.; Guengerich, F.
    Human cytochrome P450 27C1 catalyzes 3,4-desaturation of retinoids (2016), FEBS Lett., 590, 1304-1312 .
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.19.53 0.00035
-
 all-trans-retinal pH 7.4, temperature not specified in the publication Homo sapiens
1.14.19.53 0.0005
-
 all-trans-retinol pH 7.4, temperature not specified in the publication Homo sapiens
1.14.19.53 0.00087
-
 all-trans-retinoic acid pH 7.4, temperature not specified in the publication Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.53 Homo sapiens Q4G0S4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.53 all-trans-retinal + 2 reduced adrenodoxin + 2 H+ + O2
-
 Homo sapiens all-trans-3,4-didehydroretinal + 2 oxidized adrenodoxin + 2 H2O
-
 ?
1.14.19.53 all-trans-retinoic acid + 2 reduced adrenodoxin + 2 H+ + O2
-
 Homo sapiens all-trans-3,4-didehydroretinoic acid + 2 oxidized adrenodoxin + 2 H2O
-
 ?
1.14.19.53 all-trans-retinol + 2 reduced adrenodoxin + 2 H+ + O2
-
 Homo sapiens all-trans-3,4-didehydroretinol + 2 oxidized adrenodoxin + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.53 CYP27C1
-
 Homo sapiens
1.14.19.53 cytochrome P450 27C1
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.14.19.53 0.004
-
 all-trans-retinal pH 7.4, temperature not specified in the publication Homo sapiens
1.14.19.53 0.023
-
 all-trans-retinoic acid pH 7.4, temperature not specified in the publication Homo sapiens
1.14.19.53 0.38
-
 all-trans-retinol pH 7.4, temperature not specified in the publication Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.53 cytochrome P450
-
 Homo sapiens