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Literature summary extracted from

  • Larik, F.A.; Saeed, A.; Channar, P.A.; Muqadar, U.; Abbas, Q.; Hassan, M.; Seo, S.Y.; Bolte, M.
    Design, synthesis, kinetic mechanism and molecular docking studies of novel 1-pentanoyl-3-arylthioureas as inhibitors of mushroom tyrosinase and free radical scavengers (2017), Eur. J. Med. Chem., 141, 273-281 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 1-pentanoyl-3-(2,3-dichlorophenyl)thiourea
-
 Agaricus bisporus
1.14.18.1 1-pentanoyl-3-(2,4,6-trimethylphenyl)thiourea
-
 Agaricus bisporus
1.14.18.1 1-pentanoyl-3-(2,4-dinitrophenyl)thiourea
-
 Agaricus bisporus
1.14.18.1 1-pentanoyl-3-(2,6-dibromo-4-fluorophenyl)thiourea
-
 Agaricus bisporus
1.14.18.1 1-pentanoyl-3-(3-nitrophenyl)thiourea
-
 Agaricus bisporus
1.14.18.1 1-pentanoyl-3-(4-bromo-2-fluorophenyl)thiourea
-
 Agaricus bisporus
1.14.18.1 1-pentanoyl-3-(4-bromophenyl)thiourea
-
 Agaricus bisporus
1.14.18.1 1-pentanoyl-3-(4-chlorophenyl)thiourea
-
 Agaricus bisporus
1.14.18.1 1-pentanoyl-3-(4-methoxyphenyl)thiourea noncompetitive inhibition, docking interaction analysis between 1-pentanoyl-3-(4-methoxyphenyl)thiourea and mushroom tyrosinase Agaricus bisporus
1.14.18.1 1-pentanoyl-3-(4-nitrophenyl)thiourea
-
 Agaricus bisporus
1.14.18.1 kojic acid
-
 Agaricus bisporus
1.14.18.1 additional information design, synthesis, kinetic mechanism, and molecular docking studies of 1-pentanoyl-3-arylthioureas as inhibitors of mushroom tyrosinase and free radical scavengers, structure activity relationships, overview Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 mushroom tyrosinase
-
 Agaricus bisporus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.14.18.1 25
-
 assay at Agaricus bisporus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.18.1 6.8
-
 assay at Agaricus bisporus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.18.1 additional information
-
 additional information inhibition kinetics Agaricus bisporus
1.14.18.1 0.0011 0.0016 1-pentanoyl-3-(4-methoxyphenyl)thiourea pH 6.8, 25°C Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.0016
-
 pH 6.8, 25°C Agaricus bisporus 1-pentanoyl-3-(4-methoxyphenyl)thiourea
1.14.18.1 0.0023
-
 pH 6.8, 25°C Agaricus bisporus 1-pentanoyl-3-(4-chlorophenyl)thiourea
1.14.18.1 0.0034
-
 pH 6.8, 25°C Agaricus bisporus 1-pentanoyl-3-(4-bromophenyl)thiourea
1.14.18.1 0.0065
-
 pH 6.8, 25°C Agaricus bisporus 1-pentanoyl-3-(4-bromo-2-fluorophenyl)thiourea
1.14.18.1 0.0078
-
 pH 6.8, 25°C Agaricus bisporus 1-pentanoyl-3-(2,3-dichlorophenyl)thiourea
1.14.18.1 0.008
-
 pH 6.8, 25°C Agaricus bisporus 1-pentanoyl-3-(4-nitrophenyl)thiourea
1.14.18.1 0.0101
-
 pH 6.8, 25°C Agaricus bisporus 1-pentanoyl-3-(2,4-dinitrophenyl)thiourea
1.14.18.1 0.0166
-
 pH 6.8, 25°C Agaricus bisporus 1-pentanoyl-3-(3-nitrophenyl)thiourea
1.14.18.1 0.0195
-
 pH 6.8, 25°C Agaricus bisporus 1-pentanoyl-3-(2,6-dibromo-4-fluorophenyl)thiourea
1.14.18.1 0.0197
-
 pH 6.8, 25°C Agaricus bisporus 1-pentanoyl-3-(2,4,6-trimethylphenyl)thiourea