EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
6.1.1.10 | (1R,3S)-3-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) cyclohexanamine | - |
Trypanosoma brucei | |
6.1.1.10 | (R)-1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) piperidin-3-amine | - |
Trypanosoma brucei | |
6.1.1.10 | (R)-1-(5-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) pyrrolidin-3-amine | - |
Trypanosoma brucei | |
6.1.1.10 | (S)-1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) piperidin-3-amine | - |
Trypanosoma brucei | |
6.1.1.10 | (S)-1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorophenyl) piperidine-3-carboxamide | - |
Trypanosoma brucei | |
6.1.1.10 | (S)-1-(5-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) pyrrolidin-3-amine | - |
Trypanosoma brucei | |
6.1.1.10 | (S)-3,5-dichloro-N-(1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)piperidin-3-yl)benzamide | - |
Trypanosoma brucei | |
6.1.1.10 | (S)-5-chloro-2-(3-((3,5-dichlorobenzyl)oxy)piperidin-1-yl)-1H-imidazo[4,5-b]pyridine | - |
Trypanosoma brucei | |
6.1.1.10 | 1-(3-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-2-(3,5-dichlorophenyl) ethanone | - |
Trypanosoma brucei | |
6.1.1.10 | 1-(3-(4-chloro-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-2-(3,5-dichlorophenyl) ethanone | - |
Trypanosoma brucei | |
6.1.1.10 | 1-(3-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-2-(3,5-dichlorophenyl)ethanone | - |
Trypanosoma brucei | |
6.1.1.10 | 1-(3-(5-chloro-1H-benzo[d]imidazol-2-yl) piperidin-1-yl)-2-(3,5-dichlorophenyl) ethanone | - |
Trypanosoma brucei | |
6.1.1.10 | 1-(3-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)piperidin-1-yl)-2-(3,5-dichlorophenyl)ethanone | - |
Trypanosoma brucei | |
6.1.1.10 | 1-(3-(5-chloro-6-fluoro-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-2-(3,5-dichlorophenyl)ethanone | - |
Trypanosoma brucei | |
6.1.1.10 | 1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl)azepan-3-amine | - |
Trypanosoma brucei | |
6.1.1.10 | 1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl)azetidin-3-amine | - |
Trypanosoma brucei | |
6.1.1.10 | 1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl)piperidin-3-amine | - |
Trypanosoma brucei | |
6.1.1.10 | 1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl)piperidin-4-amine | - |
Trypanosoma brucei | |
6.1.1.10 | 2-((5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)thio)-N-(3,5-dichlorobenzyl) ethanamine | - |
Trypanosoma brucei | |
6.1.1.10 | 2-(3,5-dichlorophenyl)-1-(3-(5-fluoro-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethanone | - |
Trypanosoma brucei | |
6.1.1.10 | 3,5-dichloro-N-((1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)piperidin-3-yl)methyl)aniline | - |
Trypanosoma brucei | |
6.1.1.10 | 3-(5-chloro-1H-benzo[d]imidazol-2-yl)-N-(3,5-dichlorobenzyl)cyclohexanamine | - |
Trypanosoma brucei | |
6.1.1.10 | 3-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) cyclohexanamine | - |
Trypanosoma brucei | |
6.1.1.10 | 3-(5-chloro-3H-imidazo [4,5-b] pyridin-2-yl)-N-(3,5-dichlorobenzyl)propan-1-amine | - |
Trypanosoma brucei | |
6.1.1.10 | 3-(6-chloro-1H-benzo[d]imidazol-2-yl)-N-(3,5-dichlorobenzyl) propan-1-amine | - |
Trypanosoma brucei | |
6.1.1.10 | 5-chloro-2-(1-(3,5-dichlorophenethyl)piperidin-3-yl)-1H-imidazo[4,5-b]pyridine | - |
Trypanosoma brucei | |
6.1.1.10 | N1-(1H-benzimidazol-2-yl)-N3-[(3,5-dichlorophenyl)methyl]propane-1,3-diamine | - |
Trypanosoma brucei | |
6.1.1.10 | N1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N2-[(3,5-dichlorophenyl)methyl]-N1-methylethane-1,2-diamine | - |
Trypanosoma brucei | |
6.1.1.10 | N1-(5-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-N2-(3,5-dichlorobenzyl) ethane-1,2-diamine | - |
Trypanosoma brucei | |
6.1.1.10 | N1-(6-chloro-1H-benzo[d]imidazol-2-yl)-N2-(3,5-dichlorobenzyl)ethane-1,2-diamine | - |
Trypanosoma brucei | |
6.1.1.10 | [3-(1H-benzimidazol-2-yl)piperidin-1-yl](2-methyl-1-benzofuran-5-yl)methanone | 78% and 20% inhibition at 0.1 and 0.01 mM, respectively | Trypanosoma brucei |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.1.1.10 | ATP + L-methionine + tRNAMet | Trypanosoma brucei | - |
AMP + diphosphate + L-methionyl-tRNAMet | - |
? | |
6.1.1.10 | ATP + L-methionine + tRNAMet | Trypanosoma brucei 927 | - |
AMP + diphosphate + L-methionyl-tRNAMet | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.1.1.10 | Trypanosoma brucei | Q38C91 | - |
- |
6.1.1.10 | Trypanosoma brucei 927 | Q38C91 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.1.1.10 | ATP + L-methionine + tRNAMet | - |
Trypanosoma brucei | AMP + diphosphate + L-methionyl-tRNAMet | - |
? | |
6.1.1.10 | ATP + L-methionine + tRNAMet | - |
Trypanosoma brucei 927 | AMP + diphosphate + L-methionyl-tRNAMet | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.1.1.10 | methionyl-tRNA synthetase | - |
Trypanosoma brucei |
6.1.1.10 | MetRS | - |
Trypanosoma brucei |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.1.1.10 | ATP | - |
Trypanosoma brucei |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
6.1.1.10 | 0.00005 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | (S)-1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) piperidin-3-amine | |
6.1.1.10 | 0.00005 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | (S)-1-(5-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) pyrrolidin-3-amine | |
6.1.1.10 | 0.00005 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N2-[(3,5-dichlorophenyl)methyl]-N1-methylethane-1,2-diamine | |
6.1.1.10 | 0.00005 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 1-(3-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)piperidin-1-yl)-2-(3,5-dichlorophenyl)ethanone | |
6.1.1.10 | 0.00005 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl)piperidin-3-amine | |
6.1.1.10 | 0.00005 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 3,5-dichloro-N-((1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)piperidin-3-yl)methyl)aniline | |
6.1.1.10 | 0.00005 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 3-(5-chloro-3H-imidazo [4,5-b] pyridin-2-yl)-N-(3,5-dichlorobenzyl)propan-1-amine | |
6.1.1.10 | 0.00005 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N1-(6-chloro-1H-benzo[d]imidazol-2-yl)-N2-(3,5-dichlorobenzyl)ethane-1,2-diamine | |
6.1.1.10 | 0.00006 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 1-(3-(5-chloro-1H-benzo[d]imidazol-2-yl) piperidin-1-yl)-2-(3,5-dichlorophenyl) ethanone | |
6.1.1.10 | 0.000085 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | N1-(5-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-N2-(3,5-dichlorobenzyl) ethane-1,2-diamine | |
6.1.1.10 | 0.000106 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | (1R,3S)-3-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) cyclohexanamine | |
6.1.1.10 | 0.000124 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 3-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) cyclohexanamine | |
6.1.1.10 | 0.000138 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 1-(3-(5-chloro-6-fluoro-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-2-(3,5-dichlorophenyl)ethanone | |
6.1.1.10 | 0.000184 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-(3,5-dichlorophenyl)-1-(3-(5-fluoro-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)ethanone | |
6.1.1.10 | 0.000192 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | (R)-1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) piperidin-3-amine | |
6.1.1.10 | 0.000196 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | (S)-5-chloro-2-(3-((3,5-dichlorobenzyl)oxy)piperidin-1-yl)-1H-imidazo[4,5-b]pyridine | |
6.1.1.10 | 0.000243 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 3-(6-chloro-1H-benzo[d]imidazol-2-yl)-N-(3,5-dichlorobenzyl) propan-1-amine | |
6.1.1.10 | 0.000288 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 1-(3-(1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-2-(3,5-dichlorophenyl) ethanone | |
6.1.1.10 | 0.00058 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 3-(5-chloro-1H-benzo[d]imidazol-2-yl)-N-(3,5-dichlorobenzyl)cyclohexanamine | |
6.1.1.10 | 0.000682 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl)azepan-3-amine | |
6.1.1.10 | 0.000696 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | (R)-1-(5-chloro-3H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl) pyrrolidin-3-amine | |
6.1.1.10 | 0.000812 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 1-(3-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-2-(3,5-dichlorophenyl)ethanone | |
6.1.1.10 | 0.000926 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 1-(3-(4-chloro-1H-benzo[d]imidazol-2-yl)piperidin-1-yl)-2-(3,5-dichlorophenyl) ethanone | |
6.1.1.10 | 0.001054 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2-((5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)thio)-N-(3,5-dichlorobenzyl) ethanamine | |
6.1.1.10 | 0.002166 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl)azetidin-3-amine | |
6.1.1.10 | 0.00497 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorobenzyl)piperidin-4-amine | |
6.1.1.10 | 0.01 | - |
IC50 above 0.01 mM, pH and temperature not specified in the publication | Trypanosoma brucei | (S)-1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)-N-(3,5-dichlorophenyl) piperidine-3-carboxamide | |
6.1.1.10 | 0.01 | - |
IC50 above 0.01 mM, pH and temperature not specified in the publication | Trypanosoma brucei | 5-chloro-2-(1-(3,5-dichlorophenethyl)piperidin-3-yl)-1H-imidazo[4,5-b]pyridine | |
6.1.1.10 | 0.01 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | (S)-3,5-dichloro-N-(1-(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)piperidin-3-yl)benzamide |