Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Klein, D.; Pohlentz, G.; Schwarzmann, G.; Sandhoff, K.
    Substrate specificity of GM2 and GD3 synthase of Golgi vesicles derived from rat liver (1987), Eur. J. Biochem., 167, 417-424 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.92 phosphatidylglycerol stimulates the activity of GM2 synthase without disrupting the vesicular intactness Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.92 Golgi apparatus
-
Rattus norvegicus 5794
-
2.4.3.8 Golgi apparatus
-
Rattus norvegicus 5794
-

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.92 Rattus norvegicus Q10468
-
-
2.4.3.8 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.92 liver
-
Rattus norvegicus
-
2.4.3.8 liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 ganglioside GM3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramideganglioside Rattus norvegicus UDP + ganglioside GM2
-
?
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 amide 10% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside GM2 amide
-
?
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 methyl ester 13% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside GM2 methyl ester
-
?
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3 methylamide 1% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside GM2 methylamide
-
?
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside lyso-GM3 28% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside lyso-GM2
-
?
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside N-acetyl-lyso-GM3 160% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside N-acetyl-lyso-GM2
-
?
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside N-octanoyl-lyso-GM3 122% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside N-octanoyl-lyso-GM2
-
?
2.4.1.92 UDP-N-acetyl-alpha-D-galactosamine + ganglioside N1-pyrenyl-dodecanoyl-lyso-GM3 102% of the activity with ganglioside GM3 Rattus norvegicus UDP + ganglioside N1-pyrenyl-dodecanoyl-lyso-GM2
-
?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside GM3 ganglioside GM3 i.e. 1-O-[O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramideganglioside Rattus norvegicus CMP + ganglioside GD3
-
?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside GM3 amide 11% of the activity compared to ganglioside GM3 Rattus norvegicus CMP + ganglioside GD3 amide
-
?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside GM3 methyl ester 10% of the activity compared to ganglioside GM3 Rattus norvegicus CMP + ganglioside GD3 methyl ester
-
?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside GM3 methylamide 1% of the activity compared to ganglioside GM3 Rattus norvegicus CMP + ganglioside GD3 methylamide
-
?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside lyso-GM3 70% of the activity compared to ganglioside GM3 Rattus norvegicus CMP + ganglioside lyso-GD3
-
?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside N-acetyl-lyso-GM3 120% of the activity compared to ganglioside GM3 Rattus norvegicus CMP + ganglioside N-acetyl-lyso-GD3
-
?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside N-octanoyl-lyso-GM3 101% of the activity compared to ganglioside GM3 Rattus norvegicus CMP + ganglioside N-octanoyl-lyso-GD3
-
?
2.4.3.8 CMP-N-acetylneuraminate + ganglioside N1-pyrenyl-dodecanoyl-lyso-GM3 93% of the activity compared to ganglioside GM3 Rattus norvegicus CMP + ganglioside N1-pyrenyl-dodecanoyl-lyso-GD3
-
?
2.4.3.8 additional information substrate specificity is strongly determined by the negative charge of the substrate and the acyl residue in amide bond to the amino group of neuraminic acid Rattus norvegicus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.92 GM2 synthase
-
Rattus norvegicus
2.4.1.92 UDP-2-acetamido-2-deoxy-D-galactose:(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine acetamidodeoxygalactosyl-transferase
-
Rattus norvegicus
2.4.3.8 CMP-N-acetylneuraminate: N-acetyl-neuraminyl-D-galactosyl-D-glucosylceramide N-acetylneuraminyl alpha2->8 transferase
-
Rattus norvegicus
2.4.3.8 GD3 synthase
-
Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.92 37
-
assay at Rattus norvegicus
2.4.3.8 37
-
assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.92 7.35
-
assay at Rattus norvegicus