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Literature summary extracted from

  • Mirghani, R.A.; Yasar, U.; Zheng, T.; Cook, J.M.; Gustafsson, L.L.; Tybring, G.; Ericsson, O.
    Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway (2002), Drug Metab. Dispos., 30, 1368-1371 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.55 ketoconazole complete inhibition at 0.1 mM Homo sapiens
1.14.14.55 additional information not inhibited by fluvoxamine Homo sapiens
1.14.14.55 troleandomycin complete inhibition at 0.08 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.55 microsome
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.55 quinine + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.55 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.55 liver
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.55 quinine + [reduced NADPH-hemoprotein reductase] + O2
-
Homo sapiens 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.55 CYP3A4
-
Homo sapiens