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Literature summary extracted from

  • Lopez-Cruz, R.I.; Perez-Milicua, M.B.; Crocker, D.E.; Gaxiola-Robles, R.; Bernal-Vertiz, J.A.; de la Rosa, A.; Vazquez-Medina, J.P.; Zenteno-Savin, T.
    Purine nucleoside phosphorylase and xanthine oxidase activities in erythrocytes and plasma from marine, semiaquatic and terrestrial mammals (2014), Comp. Biochem. Physiol. A, 171, 31-35 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 Homo sapiens
-
 urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 Tursiops truncatus
-
 urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 Lontra longicaudis annectens
-
 urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 Mirounga angustirostris
-
 urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2 Sus scrofa
-
 urate + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Homo sapiens P47989
-
-
1.17.3.2 Lontra longicaudis annectens
-
-
-
1.17.3.2 Mirounga angustirostris H9A5F8
-
-
1.17.3.2 Sus scrofa F1S3Y7
-
-
1.17.3.2 Tursiops truncatus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 blood plasma
-
 Tursiops truncatus
-
1.17.3.2 blood plasma
-
 Lontra longicaudis annectens
-
1.17.3.2 blood plasma
-
 Sus scrofa
-
1.17.3.2 blood plasma low activity Homo sapiens
-
1.17.3.2 blood plasma enzyme activity in plasma of northern elephant seals during prolonged fasting and rest and voluntary associated apneas Mirounga angustirostris
-
1.17.3.2 erythrocyte
-
 Homo sapiens
-
1.17.3.2 erythrocyte
-
 Tursiops truncatus
-
1.17.3.2 erythrocyte
-
 Lontra longicaudis annectens
-
1.17.3.2 erythrocyte
-
 Mirounga angustirostris
-
1.17.3.2 erythrocyte
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.17.3.2 additional information
-
 mean activity in plasma is 0.34 mU/ml Tursiops truncatus
1.17.3.2 additional information
-
 mean activity in plasma is 0.36 mU/ml Sus scrofa
1.17.3.2 additional information
-
 mean activity in plasma is 0.52 mU/ml Lontra longicaudis annectens
1.17.3.2 additional information
-
 mean activity in plasma is 0.591 mU/ml Homo sapiens
1.17.3.2 additional information
-
 mean activity in plasma is 2.04 mU/ml Mirounga angustirostris

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 xanthine + H2O + O2
-
 Homo sapiens urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2
-
 Tursiops truncatus urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2
-
 Lontra longicaudis annectens urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2
-
 Mirounga angustirostris urate + H2O2
-
 ?
1.17.3.2 xanthine + H2O + O2
-
 Sus scrofa urate + H2O2
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.3.2 37
-
 assay at Homo sapiens
1.17.3.2 37
-
 assay at Tursiops truncatus
1.17.3.2 37
-
 assay at Lontra longicaudis annectens
1.17.3.2 37
-
 assay at Mirounga angustirostris
1.17.3.2 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.3.2 7.5
-
 assay at Homo sapiens
1.17.3.2 7.5
-
 assay at Tursiops truncatus
1.17.3.2 7.5
-
 assay at Lontra longicaudis annectens
1.17.3.2 7.5
-
 assay at Mirounga angustirostris
1.17.3.2 7.5
-
 assay at Sus scrofa

General Information

EC Number General Information Comment Organism
1.17.3.2 evolution analysis of circulating xanthine oxidase activities in marine mammals adapted to tolerate repeated cycles of ischemia/reperfusion associated with diving (bottlenose dolphin, northern elephant seal) in comparison with semiaquatic (river otter) and terrestrial mammals (human, pig), overview Homo sapiens
1.17.3.2 evolution analysis of circulating xanthine oxidase activities in marine mammals adapted to tolerate repeated cycles of ischemia/reperfusion associated with diving (bottlenose dolphin, northern elephant seal) in comparison with semiaquatic (river otter) and terrestrial mammals (human, pig), overview Tursiops truncatus
1.17.3.2 evolution analysis of circulating xanthine oxidase activities in marine mammals adapted to tolerate repeated cycles of ischemia/reperfusion associated with diving (bottlenose dolphin, northern elephant seal) in comparison with semiaquatic (river otter) and terrestrial mammals (human, pig), overview Lontra longicaudis annectens
1.17.3.2 evolution analysis of circulating xanthine oxidase activities in marine mammals adapted to tolerate repeated cycles of ischemia/reperfusion associated with diving (bottlenose dolphin, northern elephant seal) in comparison with semiaquatic (river otter) and terrestrial mammals (human, pig), overview Mirounga angustirostris
1.17.3.2 evolution analysis of circulating xanthine oxidase activities in marine mammals adapted to tolerate repeated cycles of ischemia/reperfusion associated with diving (bottlenose dolphin, northern elephant seal) in comparison with semiaquatic (river otter) and terrestrial mammals (human, pig), overview Sus scrofa
1.17.3.2 metabolism purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purine salvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid Tursiops truncatus
1.17.3.2 metabolism purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purine salvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid Lontra longicaudis annectens
1.17.3.2 metabolism purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purine salvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid Mirounga angustirostris
1.17.3.2 metabolism purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purine salvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid Sus scrofa
1.17.3.2 metabolism purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes involved in the purinesalvage pathway. PNP metabolizes purine bases to synthetize purine nucleotides whereas XO catalyzes the oxidation of purines to uric acid Homo sapiens