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Literature summary extracted from

  • Mirghani, R.A.; Hellgren, U.; Westerberg, P.A.; Ericsson, O.; Bertilsson, L.; Gustafsson, L.L.
    The roles of cytochrome P450 3A4 and 1A2 in the 3-hydroxylation of quinine in vivo (1999), Clin. Pharmacol. Ther., 66, 454-460 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.55 ketoconazole
-
 Homo sapiens
1.14.14.55 additional information not inhibited by fluvoxamine Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.55 quinine + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.55 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.55 blood plasma
-
 Homo sapiens
-
1.14.14.55 urine
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.55 quinine + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 3-hydroxyquinine + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.55 CYP3A4
-
 Homo sapiens
1.14.14.55 quinine monooxygenase
-
 Homo sapiens