Literature summary extracted from

Li, Z.; Martin, M.; Zhang, J.; Huang, H.Y.; Bai, L.; Zhang, J.; Kang, J.; He, M.; Li, J.; Maurya, M.R.; Gupta, S.; Zhou, G.; Sangwung, P.; Xu, Y.J.; Lei, T.; Huang, H.D.; Jain, M.; Jain, M.K.; Subramaniam, S.; Shyy, J.Y.
Krueppel-like factor 4 regulation of cholesterol-25-hydroxylase and liver X receptor mitigates atherosclerosis susceptibility (2017), Circulation, 136, 1315-1330 .

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.99.38	cholesterol + AH2 + O2	Mus musculus	-	25-hydroxycholesterol + A + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.99.38	Mus musculus	Q9Z0F5	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.99.38	endothelial cell	-	Mus musculus	-
1.14.99.38	macrophage	-	Mus musculus	-
1.14.99.38	monocyte	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.99.38	cholesterol + AH2 + O2	-	Mus musculus	25-hydroxycholesterol + A + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.99.38	CH25H	-	Mus musculus
1.14.99.38	cholesterol-25-hydroxylase	-	Mus musculus

Expression

EC Number	Organism	Comment	Expression
1.14.99.38	Mus musculus	vasoprotective stimuli such as pulsatile shear stress and statins increase the expression of the enzyme via Krueppel-like factor 4	up

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Release 2023.1 (January 2023)