Literature summary extracted from
Kavanagh, M.E.; Gray, J.L.; Gilbert, S.H.; Coyne, A.G.; McLean, K.J.; Davis, H.J.; Munro, A.W.; Abell, C.
Substrate fragmentation for the design of M. tuberculosis CYP121 inhibitors (2016), ChemMedChem, 11, 1924-1935 .
Application
EC Number |
Application |
Comment |
Organism |
---|
1.14.19.70 |
medicine |
the CYP121 gene is essential for survival of Mycobacterium tuberculosis in vitro and the enzyme is believed to be the molecular target responsible for the anti-tubercular efficacy of azole antifungal compounds pharmacology |
Mycobacterium tuberculosis |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
1.14.19.70 |
additional information |
the cyclo-dipeptide substrates of the essential Mycobacterium tuberculosis enzyme CYP121 are deconstructed into their component fragments and screened against the enzyme |
Mycobacterium tuberculosis |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
1.14.19.70 |
Mycobacterium tuberculosis |
P9WPP7 |
- |
- |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
1.14.19.70 |
CYP121 |
- |
Mycobacterium tuberculosis |