Literature summary extracted from

Lee, Y.H.; Chang, C.P.; Cheng, Y.J.; Kuo, Y.Y.; Lin, Y.S.; Wang, C.C.
Evolutionary gain of highly divergent tRNA specificities by two isoforms of human histidyl-tRNA synthetase (2017), Cell. Mol. Life Sci., 74, 2663-2677 .

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
6.1.1.21	cytosol	-	Bacillus subtilis	5829	-
6.1.1.21	cytosol	-	Homo sapiens	5829	-
6.1.1.21	mitochondrion	-	Homo sapiens	5739	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6.1.1.21	ATP + L-histidine + tRNAHis	Bacillus subtilis	-	AMP + diphosphate + L-histidyl-tRNAHis	-	?
6.1.1.21	ATP + L-histidine + tRNAHis	Homo sapiens	-	AMP + diphosphate + L-histidyl-tRNAHis	-	?
6.1.1.21	ATP + L-histidine + tRNAHis	Saccharomyces cerevisiae	-	AMP + diphosphate + L-histidyl-tRNAHis	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
6.1.1.21	Bacillus subtilis	-	-	-
6.1.1.21	Homo sapiens	-	-	-
6.1.1.21	Saccharomyces cerevisiae	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
6.1.1.21	Ni-NTA column chromatography	Bacillus subtilis
6.1.1.21	Ni-NTA column chromatography	Homo sapiens
6.1.1.21	Ni-NTA column chromatography	Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6.1.1.21	ATP + L-histidine + tRNAHis	-	Bacillus subtilis	AMP + diphosphate + L-histidyl-tRNAHis	-	?
6.1.1.21	ATP + L-histidine + tRNAHis	-	Homo sapiens	AMP + diphosphate + L-histidyl-tRNAHis	-	?
6.1.1.21	ATP + L-histidine + tRNAHis	-	Saccharomyces cerevisiae	AMP + diphosphate + L-histidyl-tRNAHis	-	?
6.1.1.21	additional information	the enzyme recognizes only tRNAHis with cytosine73 but not with adenine73	Bacillus subtilis	?	-	?
6.1.1.21	additional information	the enzyme recognizes tRNAHis with cytosine73 or adenine73	Homo sapiens	?	-	?
6.1.1.21	additional information	the enzyme recognizes tRNAHis with cytosine73 or adenine73 and a slight preference for adenine7	Saccharomyces cerevisiae	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
6.1.1.21	HisRS	-	Bacillus subtilis
6.1.1.21	HisRS	-	Homo sapiens
6.1.1.21	HisRS	-	Saccharomyces cerevisiae
6.1.1.21	Histidyl-tRNA synthetase	-	Bacillus subtilis
6.1.1.21	Histidyl-tRNA synthetase	-	Homo sapiens
6.1.1.21	Histidyl-tRNA synthetase	-	Saccharomyces cerevisiae

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
6.1.1.21	ATP	-	Bacillus subtilis
6.1.1.21	ATP	-	Homo sapiens
6.1.1.21	ATP	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)