Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ping, X.L.; Sun, B.F.; Wang, L.; Xiao, W.; Yang, X.; Wang, W.J.; Adhikari, S.; Shi, Y.; Lv, Y.; Chen, Y.S.; Zhao, X.; Li, A.; Yang, Y.; Dahal, U.; Lou, X.M.; Liu, X.; Huang, J.; Yuan, W.P.; Zhu, X.F.; Cheng, T.; Zhao, Y.L.; Wang, X.; Rendtlew Danielsen, J.M.; Liu, F.; Yang, Y.G.
    Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase (2014), Cell Res., 24, 177-189 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.348 nucleus nuclear speckles. Protein WTAP is required for nuclear speckle localization of METTL3 and METTL14 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.348 Danio rerio F1R777 subunit METTL3
-
2.1.1.348 Homo sapiens Q86U44 and Q9HCE5 Q86U44 i.e. catalytic subunit METTL3, Q9HCE5 i.e non-catalytic subunit METTL14
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.348 additional information in WTAP- and METTL3 intronic binding clusters, the RNA motifs AGGACU and UGUGGACU are enriched. The highest scoring motif found in both WTAP- and METTL3-binding clusters is UUAGGACU. In addition, AGGAC, UGGAC, and AGACUAA are also highly enriched in WTAP, METTL3 and WTAP/METTL3 overlay clusters, respectively Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.348 METTL3
-
 Danio rerio

General Information

EC Number General Information Comment Organism
2.1.1.348 physiological function morpholino-mediated knockdown targeting Wilms' tumor 1-associating protein WTAP and/or METTL3 in zebrafish embryos causes tissue differentiation defects and increases apoptosis Danio rerio
2.1.1.348 physiological function Wilms' tumor 1-associating protein (WTAP) interacts with METTL3 and METTL14, and is required for their localization into nuclear speckles enriched with pre-mRNA processing factors and for catalytic activity of the m6A methyltransferase in vivo. In the absence of WTAP, the RNA-binding capability of METTL3 is strongly reduced. In addition, WTAP and METTL3 regulate expression and alternative splicing of genes involved in transcription and RNA processing Homo sapiens