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Literature summary extracted from

  • Koeth, R.; Levison, B.; Culley, M.; Buffa, J.; Wang, Z.; Gregory, J.; Org, E.; Wu, Y.; Li, L.; Smith, J.; Tang, W.; Didonato, J.; Lusis, A.; Hazen, S.
    gamma-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO (2014), Cell Metab., 20, 799-812 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.13.239 expressed in Escherichia coli BL21pLysS cells Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.239 L-carnitine + NADH + H+ + O2 Escherichia coli
-
 (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADH + H+ + O2 Escherichia coli DH10B
-
 (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADPH + H+ + O2 Escherichia coli
-
 (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADPH + H+ + O2 Escherichia coli DH10B
-
 (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.239 Escherichia coli
-
-
-
1.14.13.239 Escherichia coli DH10B
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.239 L-carnitine + NADH + H+ + O2
-
 Escherichia coli (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADH + H+ + O2
-
 Escherichia coli DH10B (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NAD+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADPH + H+ + O2
-
 Escherichia coli (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
 ?
1.14.13.239 L-carnitine + NADPH + H+ + O2
-
 Escherichia coli DH10B (3R)-3-hydroxy-4-oxobutanoate + trimethylamine + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.239 carnitine TMA lyase
-
 Escherichia coli
1.14.13.239 yeaWX
-
 Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.239 NADH
-
 Escherichia coli
1.14.13.239 NADPH
-
 Escherichia coli