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Literature summary extracted from

  • Yang, W.H.; Nussbaum, C.; Grewal, P.K.; Marth, J.D.; Sperandio, M.
    Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands (2012), Blood, 120, 1015-1026 .
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.6 Golgi apparatus
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 Mus musculus 5794
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Organism

EC Number Organism UniProt Comment Textmining
2.4.3.6 Mus musculus Q91Y74
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.6 colon
-
 Mus musculus
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2.4.3.6 lung
-
 Mus musculus
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2.4.3.6 salivary gland
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 Mus musculus
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2.4.3.6 small intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.6 CMP-N-acetylneuraminate + beta-D-Gal-(1->4)-beta-D-GlcNAc-R the alpha-2,3-sialyltransferase ST3Gal-IV can sialylate the type II glycan chains (beta-D-Gal-(1->4)-beta-D-GlcNAc) that are part of the glycan linkages of sialyl Lewis X Mus musculus CMP + alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-R
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.6 ST3Gal-IV
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.4.3.6 malfunction absence of both alpha-2,3-sialyltransferase ST3Gal-VI and alpha-2,3-sialyltransferase ST3Gal-IV results in total loss of E-selectin ligands but incomplete loss of P-selectin ligands. Loss of ST3Gal-VI and ST3Gal-IV leads to reduced cellularity of secondary lymphatic tissue Mus musculus
2.4.3.6 metabolism alpha-2,3-sialyltransferase ST3Gal-VI and alpha-2,3-sialyltransferase ST3Gal-IV participate in leukocyte sialylation. ST3Gal-IV and -VI contribute to leukocyte rolling during inflammation. ST3Gal-IV and ST3Gal-VI have a critical role in neutrophil, but not in monocyte, recruitment during inflammation. ST3Gal-VI and ST3Gal-IV have a critical role in L-selectin ligand synthesis in high endothelial venules. ST3Gal-VI and ST3Gal-IV regulate lymphocyte homing to lymph nodes and Peyer patches in vivo. Coordinated participation of both alpha-2,3-sialyltransferase ST3Gal-VI and alpha-2,3-sialyltransferase ST3Gal-IV in the synthesis of functional selectin ligands Mus musculus