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Literature summary extracted from

  • Tieu, W.; Jarrad, A.M.; Paparella, A.S.; Keeling, K.A.; Soares da Costa, T.P.; Wallace, J.C.; Booker, G.W.; Polyak, S.W.; Abell, A.D.
    Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase (2014), Bioorg. Med. Chem. Lett., 24, 4689-4693 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.4.15 5-chloro-3-[4-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one not inhibitory to human enzyme at 0.08 mM Staphylococcus aureus
6.3.4.15 5-methyl-3-[4-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one not inhibitory to human enzyme at 0.08 mM Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
6.3.4.15 Staphylococcus aureus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
6.3.4.15 BPL
-
Staphylococcus aureus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.3.4.15 0.00009
-
pH not specified in the publication, temperature not specified in the publication Staphylococcus aureus 5-methyl-3-[4-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one
6.3.4.15 0.0006
-
pH not specified in the publication, temperature not specified in the publication Staphylococcus aureus 5-chloro-3-[4-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one