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Literature summary extracted from

  • Sun, S.; Zhang, Z.; Pokrovskaia, N.; Chowdhury, S.; Jia, Q.; Chang, E.; Khakh, K.; Kwan, R.; McLaren, D.G.; Radomski, C.C.; Ratkay, L.G.; Fu, J.; Dales, N.A.; Winther, M.D.
    Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors (2015), Bioorg. Med. Chem., 23, 455-465 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.1 2-(1-((2,2-difluorocyclopropyl)methyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-((2,2-difluorocyclopropyl)methyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(1-(4-fluorophenyl)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(1-(4-fluorophenyl)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(2-(4-fluorophenoxy)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(2-(4-fluorophenoxy)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(3,5-difluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(3,5-difluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((2-methylthiazol-5-yl)methyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((2-methylthiazol-5-yl)methyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((3-methyl-1H-pyrazol-5-yl)methyl)-thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((3-methyl-1H-pyrazol-5-yl)methyl)-thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((5-methylpyrazin-2-yl)methyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((5-methylpyrazin-2-yl)methyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-2-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-2-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-4-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-4-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(piperidin-3-ylmethyl)thiazole-5-carboxamide trifluoroacetic acid salt
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(piperidin-3-ylmethyl)thiazole-5-carboxamide trifluoroacetic acid salt
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(thiazol-2-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(thiazol-2-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-(1-(cyclopropylmethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 2-(1-(cyclopropylmethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 2-benzamido-4-methyl-N-phenylthiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazole-5-carboxamide
-
 Mus musculus
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(oxazol-4-ylmethyl)-1H-pyrazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(oxazol-4-ylmethyl)-1H-pyrazole-5-carboxamide
-
 Mus musculus
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)-1H-pyrazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)-1H-pyrazole-5-carboxamide
-
 Mus musculus
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide
-
 Mus musculus
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-4-ylmethyl)-1H-pyrazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-4-ylmethyl)-1H-pyrazole-5-carboxamide
-
 Mus musculus
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-methyl-1H-pyrazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-methyl-1H-pyrazole-5-carboxamide
-
 Mus musculus
1.14.19.1 4-methyl-2-(5-oxo-1-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 4-methyl-2-(5-oxo-1-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 4-methyl-2-(5-oxo-1-(4,4,4-trifluorobutyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 4-methyl-2-(5-oxo-1-(4,4,4-trifluorobutyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 additional information synthesis and structure-activity relationships of a series of triazolone derivatives as enzyme inhibitors, overview Homo sapiens
1.14.19.1 additional information synthesis and structure-activity relationships of a series of triazolone derivatives as enzyme inhibitors, overview Mus musculus
1.14.19.1 N-((1H-pyrazol-3-yl)methyl)-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
-
 Homo sapiens
1.14.19.1 N-((1H-pyrazol-3-yl)methyl)-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
-
 Mus musculus
1.14.19.1 N-benzyl-2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxamide
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.1 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.14.19.1 microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Mus musculus
-
 palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.1 palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Homo sapiens
-
 palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Mus musculus
-
 oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Homo sapiens
-
 oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Homo sapiens O00767
-
-
1.14.19.1 Mus musculus P13516
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 Hep-G2 cell
-
 Homo sapiens
-
1.14.19.1 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Mus musculus palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.1 palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Homo sapiens palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Mus musculus oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Homo sapiens oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD1
-
 Mus musculus
1.14.19.1 SCD1
-
 Homo sapiens
1.14.19.1 stearoyl-CoA desaturase-1
-
 Mus musculus
1.14.19.1 stearoyl-CoA desaturase-1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 cytochrome b5
-
 Mus musculus
1.14.19.1 cytochrome b5
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.19.1 0.000007
-
 pH and temperature not specified in the publication Mus musculus 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide
1.14.19.1 0.000007
-
 pH and temperature not specified in the publication Mus musculus 4-methyl-2-(5-oxo-1-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000008
-
 pH and temperature not specified in the publication Homo sapiens 4-methyl-2-(5-oxo-1-((5-(trifluoromethyl)furan-2-yl)methyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000009
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(2-(4-fluorophenoxy)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000009
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((3-methyl-1H-pyrazol-5-yl)methyl)-thiazole-5-carboxamide
1.14.19.1 0.000009
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(thiazol-2-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000012
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-4-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000012
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(thiazol-2-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000014
-
 pH and temperature not specified in the publication Mus musculus 4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000015
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(2-(4-fluorophenoxy)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000015
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((5-methylpyrazin-2-yl)methyl)thiazole-5-carboxamide
1.14.19.1 0.000016
-
 pH and temperature not specified in the publication Mus musculus 4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000019
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(3,5-difluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000019
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)thiazole-5-carboxamide
1.14.19.1 0.00002
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000021
-
 pH and temperature not specified in the publication Mus musculus 4-methyl-2-(5-oxo-1-(4,4,4-trifluorobutyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000022
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-2-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000022
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000023
-
 pH and temperature not specified in the publication Mus musculus 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)-1H-pyrazole-5-carboxamide
1.14.19.1 0.000024
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((2-methylthiazol-5-yl)methyl)thiazole-5-carboxamide
1.14.19.1 0.000027
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)thiazole-5-carboxamide
1.14.19.1 0.00003
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(1-(4-fluorophenyl)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000032
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((2-methylthiazol-5-yl)methyl)thiazole-5-carboxamide
1.14.19.1 0.000039
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-4-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000046
-
 pH and temperature not specified in the publication Homo sapiens 4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000046
-
 pH and temperature not specified in the publication Mus musculus N-((1H-pyrazol-3-yl)methyl)-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
1.14.19.1 0.000055
-
 pH and temperature not specified in the publication Mus musculus 2-(1-((2,2-difluorocyclopropyl)methyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000065
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
1.14.19.1 0.000066
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(1-(4-fluorophenyl)ethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000067
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000098
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(cyclopropylmethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000103
-
 pH and temperature not specified in the publication Homo sapiens 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)-1H-pyrazole-5-carboxamide
1.14.19.1 0.000105
-
 pH and temperature not specified in the publication Homo sapiens N-((1H-pyrazol-3-yl)methyl)-2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
1.14.19.1 0.000125
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(3,5-difluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.00014
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(cyclopropylmethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000147
-
 pH and temperature not specified in the publication Mus musculus 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)-1H-pyrazole-5-carboxamide
1.14.19.1 0.000165
-
 pH and temperature not specified in the publication Mus musculus 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(oxazol-4-ylmethyl)-1H-pyrazole-5-carboxamide
1.14.19.1 0.000194
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((5-methylpyrazin-2-yl)methyl)thiazole-5-carboxamide
1.14.19.1 0.000214
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(oxazol-2-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000227
-
 pH and temperature not specified in the publication Homo sapiens 4-methyl-2-(5-oxo-1-(4-(trifluoromethyl)benzyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000268
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.00028
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((3-methyl-1H-pyrazol-5-yl)methyl)-thiazole-5-carboxamide
1.14.19.1 0.000306
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-((2,2-difluorocyclopropyl)methyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000385
-
 pH and temperature not specified in the publication Mus musculus 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-methyl-1H-pyrazole-5-carboxamide
1.14.19.1 0.000398
-
 pH and temperature not specified in the publication Homo sapiens 4-methyl-2-(5-oxo-1-(4,4,4-trifluorobutyl)-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide
1.14.19.1 0.000477
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-pyrazol-4-yl)methyl)thiazole-5-carboxamide
1.14.19.1 0.000504
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((1-methyl-1H-imidazol-4-yl)methyl)thiazole-5-carboxamide
1.14.19.1 0.00072
-
 pH and temperature not specified in the publication Homo sapiens 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-2-ylmethyl)-1H-pyrazole-5-carboxamide
1.14.19.1 0.000945
-
 pH and temperature not specified in the publication Homo sapiens 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxamide
1.14.19.1 0.001722
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)-thiazole-5-carboxamide
1.14.19.1 0.002673
-
 pH and temperature not specified in the publication Mus musculus 3-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-4-ylmethyl)-1H-pyrazole-5-carboxamide
1.14.19.1 0.01
-
 pH and temperature not specified in the publication Mus musculus 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methyl-N-(piperidin-3-ylmethyl)thiazole-5-carboxamide trifluoroacetic acid salt

General Information

EC Number General Information Comment Organism
1.14.19.1 malfunction inhibition of SCD1 activity represents a potential novel approach for the treatment of metabolic diseases such as obesity, type 2 diabetes and dyslipidemia, as well as skin diseases, acne and cancer Mus musculus
1.14.19.1 malfunction inhibition of SCD1 activity represents a potential novel approach for the treatment of metabolic diseases such as obesity, type 2 diabetes and dyslipidemia, as well as skin diseases, acne and cancer Homo sapiens
1.14.19.1 metabolism stearoyl-CoA desaturase-1 (SCD1) plays an important role in lipid metabolism Mus musculus
1.14.19.1 metabolism stearoyl-CoA desaturase-1 (SCD1) plays an important role in lipid metabolism Homo sapiens