Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Ortiz-Ruiz, C.V.; Berna, J.; Garcia-Molina, M.d.e.l. .M.; Tudela, J.; Tomas, V.; Garcia-Canovas, F.
    Identification of p-hydroxybenzyl alcohol, tyrosol, phloretin and its derivate phloridzin as tyrosinase substrates (2015), Bioorg. Med. Chem., 23, 3738-3746 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 4-Hydroxybenzyl alcohol the compound is a substrate and an inhibitor for tyrosinase, 39% inhibition at 1.5 mM Agaricus bisporus
1.14.18.1 additional information true inhibitors of tyrosinase diminish the rate of action of the enzyme when it acts on either of its physiological substrates, L-tyrosine (monophenolase activity) or L-dopa (diphenolase activity) Agaricus bisporus
1.14.18.1 phenylacetic acid
-
 Agaricus bisporus
1.14.18.1 phloretin the compound is a substrate and an inhibitor for tyrosinase, 63% inhibition at 0.2 mM Agaricus bisporus
1.14.18.1 phloridzin the compound is a substrate and an inhibitor for tyrosinase, 53% inhibition at 0.15 mM Agaricus bisporus
1.14.18.1 tyrosol the compound is a substrate and an inhibitor for tyrosinase, 18% inhibition at 1.5 mM Agaricus bisporus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.18.1 Cu2+ a copper-containing enzyme Agaricus bisporus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.18.1 2 L-dopa + O2 Agaricus bisporus
-
 2 dopaquinone + 2 H2O
-
 ?
1.14.18.1 tyrosine + O2 Agaricus bisporus
-
 dopaquinone + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.18.1 2 L-dopa + O2 = 2 dopaquinone + 2 H2O mechanism of tyrosinase on monophenols and o-diphenol, overview Agaricus bisporus
a
1.14.18.1 L-tyrosine + O2 = dopaquinone + H2O mechanism of tyrosinase on monophenols and o-diphenol, overview Agaricus bisporus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.18.1 commercial preparation
-
 Agaricus bisporus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 2 L-dopa + O2
-
 Agaricus bisporus 2 dopaquinone + 2 H2O
-
 ?
1.14.18.1 4-hydroxybenzyl alcohol + O2 the compound is a substrate and an inhibitor for tyrosinase Agaricus bisporus ?
-
 ?
1.14.18.1 phloretin + O2 the compound is a substrate and an inhibitor for tyrosinase Agaricus bisporus ?
-
 ?
1.14.18.1 phloridzin + O2 the compound is a substrate and an inhibitor for tyrosinase Agaricus bisporus ?
-
 ?
1.14.18.1 tyrosine + O2
-
 Agaricus bisporus dopaquinone + H2O
-
 ?
1.14.18.1 tyrosol + O2 the compound is a substrate and an inhibitor for tyrosinase Agaricus bisporus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 mushroom tyrosinase
-
 Agaricus bisporus

General Information

EC Number General Information Comment Organism
1.14.18.1 physiological function tyrosinase is a copper-containing enzyme widely distributed in nature, where it catalyses two types of reaction: (a) the ortho-hydroxylation of monophenols (L-tyrosine) to o-diphenols (L-dopa), monophenolase activity, and (b) the oxidation of o-diphenols (L-dopa) to o-quinones (L-dopaquinone), diphenolase activity. Both types of reaction require molecular oxygen as the second substrate of the enzyme. The o-dopaquinone produced from L-tyrosine and L-dopa rapidly evolves to dopachrome Agaricus bisporus