BRENDA - Enzyme Database show

Identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as Mycobacterium tuberculosis pantothenate synthetase inhibitors

Samala, G.; Nallangi, R.; Devi, P.B.; Saxena, S.; Yadav, R.; Sridevi, J.P.; Yogeeswari, P.; Sriram, D.; Bioorg. Med. Chem. 22, 4223-4232 (2014)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
6.3.2.1
2,6-dimethyl-N-(thiophen-2-ylmethyl)-2H,3H-imidazo[1,2-a]pyridine-3-carboxamide
GSK358607A, MIC value is 190 nM
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(3,4,5-trimethoxybenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(3-nitrobenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-(trifluoromethyl)benzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-methylbenzoyl)imidazo[1,2-a]pyridine-
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-methylbenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-methylbenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-nitrobenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-phenoxybenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N-(pyridin-2-yl)imidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N-phenethylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N-phenylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
6-acetyl-2-(thiophene-2-carboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
SID 92097880, MIC values is 0.0032 mM
Mycobacterium tuberculosis
6.3.2.1
ethambutol
-
Mycobacterium tuberculosis
6.3.2.1
isoniazid
-
Mycobacterium tuberculosis
6.3.2.1
additional information
usage of the crystal structure of mycobacterial pantothenate synthetase bound with 2-(2-(benzofuran-2-ylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl) acetic acid inhibitor for virtual screening of an antitubercular compound database, identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as inhibitors of Mycobacterium tuberculosis pantothenate synthetase, synthesis of 30 derivatives and evaluation as inhibitors, inhibition study of in vitro anti-TB activities against replicative and non-replicative MTB, in vivo activity using Mycobacterium marinum infected Zebra fish, and cytotoxicity against RAW 264.7 cell line, overview
Mycobacterium tuberculosis
6.3.2.1
N'-(1-naphthoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(2,4-dichlorobenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(2-methoxybenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(3,5-dinitrobenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(4-(benzyloxy)benzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(4-bromobenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(4-fluorobenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(4-hydroxybenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(4-methoxybenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(cyclohexanecarbonyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(furan-2-carbonyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-benzoyl-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-benzylidene-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N-(4-bromophenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
N-(4-chlorophenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
N-(4-ethoxyphenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
N-(furan-2-ylmethyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
N-benzyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
N-cyclohexyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
6.3.2.1
Mg2+
required
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6.3.2.1
ATP + (R)-pantoate + beta-alanine
Mycobacterium tuberculosis
-
AMP + diphosphate + (R)-pantothenate
-
-
?
6.3.2.1
ATP + (R)-pantoate + beta-alanine
Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv
-
AMP + diphosphate + (R)-pantothenate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
6.3.2.1
Mycobacterium tuberculosis
P9WIL5
-
-
6.3.2.1
Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv
P9WIL5
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6.3.2.1
ATP + (R)-pantoate + beta-alanine
-
744484
Mycobacterium tuberculosis
AMP + diphosphate + (R)-pantothenate
-
-
-
?
6.3.2.1
ATP + (R)-pantoate + beta-alanine
-
744484
Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv
AMP + diphosphate + (R)-pantothenate
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
6.3.2.1
37
-
assay at
Mycobacterium tuberculosis
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.3.2.1
7.8
-
assay at
Mycobacterium tuberculosis
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
6.3.2.1
ATP
-
Mycobacterium tuberculosis
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
6.3.2.1
0.0019
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(1-naphthoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00199
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-cyclohexyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.0026
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-(4-chlorophenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00274
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-benzyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00281
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-(furan-2-ylmethyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00335
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(4-methylbenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00354
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-benzoyl-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00377
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(4-fluorobenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00443
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(4-bromobenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00486
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-benzylidene-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00513
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(2,4-dichlorobenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00537
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(4-(benzyloxy)benzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00577
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N-phenethylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00637
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(4-methoxybenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00648
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(3,5-dinitrobenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00695
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-(4-bromophenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00701
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00705
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(3,4,5-trimethoxybenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00722
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(4-phenoxybenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00746
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(4-methylbenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00749
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(4-hydroxybenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.0077
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(cyclohexanecarbonyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00818
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(4-(trifluoromethyl)benzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00821
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(2-methoxybenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00893
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(furan-2-carbonyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.0092
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(3-nitrobenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.01283
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N-phenylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.025
-
above, pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(4-nitrobenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.025
-
above, pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N-(pyridin-2-yl)imidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.025
-
above, pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
ethambutol
6.3.2.1
0.025
-
above, pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
isoniazid
6.3.2.1
0.025
-
above, pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-(4-ethoxyphenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
6.3.2.1
ATP
-
Mycobacterium tuberculosis
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
6.3.2.1
0.0019
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(1-naphthoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00199
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-cyclohexyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.0026
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-(4-chlorophenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00274
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-benzyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00281
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-(furan-2-ylmethyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00335
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(4-methylbenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00354
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-benzoyl-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00377
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(4-fluorobenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00443
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(4-bromobenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00486
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-benzylidene-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00513
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(2,4-dichlorobenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00537
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(4-(benzyloxy)benzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00577
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N-phenethylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00637
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(4-methoxybenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00648
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(3,5-dinitrobenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00695
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-(4-bromophenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00701
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.00705
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(3,4,5-trimethoxybenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00722
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(4-phenoxybenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00746
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(4-methylbenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00749
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(4-hydroxybenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.0077
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(cyclohexanecarbonyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00818
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(4-(trifluoromethyl)benzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00821
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(2-methoxybenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.00893
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N'-(furan-2-carbonyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.0092
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(3-nitrobenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.01283
-
pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N-phenylimidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.025
-
above, pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N'-(4-nitrobenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
6.3.2.1
0.025
-
above, pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
2-methyl-N-(pyridin-2-yl)imidazo[1,2-a]pyridine-3-carboxamide
6.3.2.1
0.025
-
above, pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
ethambutol
6.3.2.1
0.025
-
above, pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
isoniazid
6.3.2.1
0.025
-
above, pH 7.8, 37°C, recombinant enzyme
Mycobacterium tuberculosis
N-(4-ethoxyphenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
6.3.2.1
2,6-dimethyl-N-(thiophen-2-ylmethyl)-2H,3H-imidazo[1,2-a]pyridine-3-carboxamide
GSK358607A, MIC value is 190 nM
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(3,4,5-trimethoxybenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(3-nitrobenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-(trifluoromethyl)benzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-methylbenzoyl)imidazo[1,2-a]pyridine-
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-methylbenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-methylbenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-nitrobenzylidene)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N'-(4-phenoxybenzoyl)imidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N-(pyridin-2-yl)imidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N-phenethylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
2-methyl-N-phenylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
6-acetyl-2-(thiophene-2-carboxamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
SID 92097880, MIC values is 0.0032 mM
Mycobacterium tuberculosis
6.3.2.1
ethambutol
-
Mycobacterium tuberculosis
6.3.2.1
isoniazid
-
Mycobacterium tuberculosis
6.3.2.1
additional information
usage of the crystal structure of mycobacterial pantothenate synthetase bound with 2-(2-(benzofuran-2-ylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl) acetic acid inhibitor for virtual screening of an antitubercular compound database, identification and development of 2-methylimidazo[1,2-a]pyridine-3-carboxamides as inhibitors of Mycobacterium tuberculosis pantothenate synthetase, synthesis of 30 derivatives and evaluation as inhibitors, inhibition study of in vitro anti-TB activities against replicative and non-replicative MTB, in vivo activity using Mycobacterium marinum infected Zebra fish, and cytotoxicity against RAW 264.7 cell line, overview
Mycobacterium tuberculosis
6.3.2.1
N'-(1-naphthoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(2,4-dichlorobenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(2-methoxybenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(3,5-dinitrobenzoyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(4-(benzyloxy)benzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(4-bromobenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(4-fluorobenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(4-hydroxybenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(4-methoxybenzylidene)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(cyclohexanecarbonyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-(furan-2-carbonyl)-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-benzoyl-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N'-benzylidene-2-methylimidazo[1,2-a]pyridine-3-carbohydrazide
-
Mycobacterium tuberculosis
6.3.2.1
N-(4-bromophenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
N-(4-chlorophenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
N-(4-ethoxyphenyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
N-(furan-2-ylmethyl)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
N-benzyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
6.3.2.1
N-cyclohexyl-2-methylimidazo[1,2-a]pyridine-3-carboxamide
-
Mycobacterium tuberculosis
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
6.3.2.1
Mg2+
required
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
6.3.2.1
ATP + (R)-pantoate + beta-alanine
Mycobacterium tuberculosis
-
AMP + diphosphate + (R)-pantothenate
-
-
?
6.3.2.1
ATP + (R)-pantoate + beta-alanine
Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv
-
AMP + diphosphate + (R)-pantothenate
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
6.3.2.1
ATP + (R)-pantoate + beta-alanine
-
744484
Mycobacterium tuberculosis
AMP + diphosphate + (R)-pantothenate
-
-
-
?
6.3.2.1
ATP + (R)-pantoate + beta-alanine
-
744484
Mycobacterium tuberculosis ATCC 27294 / ATCC 25618 / H37Rv
AMP + diphosphate + (R)-pantothenate
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
6.3.2.1
37
-
assay at
Mycobacterium tuberculosis
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
6.3.2.1
7.8
-
assay at
Mycobacterium tuberculosis