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Literature summary extracted from

  • Kostevich, V.A.; Sokolov, A.V.; Kozlov, S.O.; Vlasenko, A.Y.; Kolmakov, N.N.; Zakharova, E.T.; Vasilyev, V.B.
    Functional link between ferroxidase activity of ceruloplasmin and protective effect of apo-lactoferrin studying rats kept on a silver chloride diet (2016), Biometals, 29, 691-704 .
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.16.3.1 lactoferrin enhances the ferroxidase activity of ceruloplasmin Rattus norvegicus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.16.3.1 purified recombinant E57A/E136A/D140A mutant ferritin, X-ray diffraction structure determination and analysis Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.16.3.1 Ag+ in ceruloplasmin, purified from sera of Ag-rats, two copper ions are substituted with two silver ions Rattus norvegicus
1.16.3.1 NaN3 efficient inhibition Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.16.3.1 Cu2+ dependent on Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.16.3.1 4 Fe(II) + 4 H+ + O2 Rattus norvegicus
-
 4 Fe(III) + 2 H2O
-
 ?
1.16.3.1 4 Fe(II) + 4 H+ + O2 Rattus norvegicus Wistar
-
 4 Fe(III) + 2 H2O
-
 ?
1.16.3.1 additional information Rattus norvegicus both in vitro and in vivo ceruloplasmin is able to form the specific complex with lactoferrin, the cationic transferrin of exocrine secretions and secretory granules of neutrophils ?
-
 ?
1.16.3.1 additional information Rattus norvegicus Wistar both in vitro and in vivo ceruloplasmin is able to form the specific complex with lactoferrin, the cationic transferrin of exocrine secretions and secretory granules of neutrophils ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.16.3.1 Rattus norvegicus P13635
-
-
1.16.3.1 Rattus norvegicus Wistar P13635
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.16.3.1 native enzyme from rat blood serum of untreated and Ag-treated animals by ion exchange chromatography and neomycin affinity chromatography Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.16.3.1 blood serum
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.16.3.1 4 Fe(II) + 4 H+ + O2
-
 Rattus norvegicus 4 Fe(III) + 2 H2O
-
 ?
1.16.3.1 4 Fe(II) + 4 H+ + O2
-
 Rattus norvegicus Wistar 4 Fe(III) + 2 H2O
-
 ?
1.16.3.1 additional information both in vitro and in vivo ceruloplasmin is able to form the specific complex with lactoferrin, the cationic transferrin of exocrine secretions and secretory granules of neutrophils Rattus norvegicus ?
-
 ?
1.16.3.1 additional information both in vitro and in vivo ceruloplasmin is able to form the specific complex with lactoferrin, the cationic transferrin of exocrine secretions and secretory granules of neutrophils Rattus norvegicus Wistar ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.16.3.1 ceruloplasmin
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.16.3.1 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.16.3.1 5.5
-
 assay at Rattus norvegicus

Expression

EC Number Organism Comment Expression
1.16.3.1 Rattus norvegicus HIF-1a and its homologue HIF-2a enhance the transcription of ceruloplasmin up

General Information

EC Number General Information Comment Organism
1.16.3.1 malfunction strongly pronounced argyrosis caused by adding AgCl to the feed of laboratory rats efficiently mimics the deficiency of ceruloplasmin ferroxidase activity. The deficiency of ceruloplasmin ferroxidase activity in Ag-fed rats affects the iron content in serum, though does not prevent the recovery of hemoglobin level accompanied by exhaustion of iron caches in liver and spleen. When apolactoferrin (apo-LF) is administered to Ag-rats suffering from either post-hemorrhagic or hemolytic anemia, both hemoglobin and serum iron are restored more rapidly than in the control animals. Saturation of apo-LF with iron, provided by active ceruloplasmin, can strongly affect its protective capacity. Phenotype, overview Rattus norvegicus