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Literature summary extracted from

  • Aardema, H.; van Tol, H.T.A.; Wubbolts, R.W.; Brouwers, J.F.H.M.; Gadella, B.M.; Roelen, B.A.J.
    Stearoyl-CoA desaturase activity in bovine cumulus cells protects the oocyte against saturated fatty acid stress (2017), Biol. Reprod., 96, 982-992 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.1 gene SCD, quantitative real-time PCR expression analysis Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.1 palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Bos taurus
-
 palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ Bos taurus
-
 oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.1 Bos taurus Q9TT94
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.1 cumulus cell
-
 Bos taurus
-
1.14.19.1 cumulus-oocyte complex the level of SCD protein expression in cumulus cells does not change when cumulus-oocyte complexes (COCs) are exposed to saturated stearic acid during maturation Bos taurus
-
1.14.19.1 oocyte low level expression Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.1 palmitoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Bos taurus palmitoleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?
1.14.19.1 stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Bos taurus oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.1 SCD
-
 Bos taurus
1.14.19.1 SCD1
-
 Bos taurus
1.14.19.1 stearoyl-CoA desaturase
-
 Bos taurus
1.14.19.1 stearoyl-CoA desaturase 1
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.1 cytochrome b5
-
 Bos taurus

General Information

EC Number General Information Comment Organism
1.14.19.1 malfunction chemical SCD1 inhibition in the presence of stearic acid results in a significant induction of apoptosis in cumulus cells of matured cumulus-oocyte complexes. SCD1 inhibition does not affect the levels of palmitic acid and its desaturated form, palmitoleic acid Bos taurus
1.14.19.1 physiological function cumulus cells can desaturate the potentially toxic stearic acid into oleic acid via stearoyl-CoA desaturase (SCD) activity, cumulus cells protect the oocyte against toxicity by saturated fatty acids. Stearoyl-CoA desaturase 1 activity is related with increased lipid storage in cumulus cells. The level of SCD protein expression in cumulus cells does not change when cumulus-oocyte complexes (COCs) are exposed to saturated stearic acid during maturation Bos taurus