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Literature summary extracted from

  • Choi, J.Y.; Jo, S.A.
    KDM7A histone demethylase mediates TNF-alpha-induced ICAM1 protein upregulation by modulating lysosomal activity (2016), Biochem. Biophys. Res. Commun., 478, 1355-1362 .
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.65 gene KDM7A, quantitative RT-PCR enzyme expression analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.11.65 additional information knockdown of KDM7A by siRNA transfection Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.65 lysosome
-
 Homo sapiens 5764
-
1.14.11.65 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.65 histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 Homo sapiens
-
 histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.65 Homo sapiens Q6ZMT4
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.65 brain
-
 Homo sapiens
-
1.14.11.65 microvascular endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.65 histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2
-
 Homo sapiens histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.65 KDM7A
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.11.65 malfunction knockdown of KDM7A by a small interfering RNA reduces the ICAM1 protein level and leukocyte adhesion without an effect on ICAM1 mRNA expression. In contrast, a KDM1B knockdown does not affect TNF-alpha-induced ICAM1 expression. Lysosome inhibitors increase the TNF-alpha-induced ICAM1 protein level and restore KDM7A knockdown-induced downregulation of ICAM1. In contrast, the KDM7A knockdown has no effect on proteasome-mediated ICAM1 degradation, but knockdown of KDM7A enhances CHX-induced ICAM1 protein degradation Homo sapiens
1.14.11.65 physiological function histone demethylase KDM7A mediates TNF-alpha-induced ICAM1 protein upregulation by modulating lysosomal activity. KDM7A-mediated ICAM1 protein upregulation is likely related to protein stability, not a histone-mediated epigenetic mechanism, role of KDM7A in ICAM1 protein stabilization via a lysosome-dependent pathway, overview Homo sapiens